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http://dx.doi.org/10.5012/bkcs.2003.24.8.1169

Synthesis of L-Ascorbic Acid Derivative Including 3-Aminopropane Phosphoric Acid as a Novel Whitening Agent  

Kang, Hak-Hee (Department of Chemical Engineering, College of Engineering, Hanyang University)
Oh, Seong-Geun (Department of Chemical Engineering, College of Engineering, Hanyang University)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.8, 2003 , pp. 1169-1171 More about this Journal
Abstract
A stable derivative of L-ascorbic acid, 2-O-[(3-aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP), was synthesized in moderate yield and its chemical stability and effects on melanin synthesis were investigated. LAscorbic acid was decomposed completely within about 1 hour, while 93% of LAAP remained even after 10 days. Treatment of L-ascorbic acid and LAAP decreased melanin content in normal human melanocytes to 33.8% and 49.1% of control at 2 mM, respectively. Considering chemical instability of L-ascorbic acid, LAAP is a much better whitening agent.
Keywords
2-O-[(3-Aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP); Whitening agent;
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Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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