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http://dx.doi.org/10.5012/bkcs.2003.24.5.623

Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC  

Paik, Seung-Uk (Faculty of Chemical & Materials Engineering, Keimyung University)
Park, Myung-Kwang (Faculty of Chemical & Materials Engineering, Keimyung University)
Jhun, Seong-Hoon (Faculty of Chemical & Materials Engineering, Keimyung University)
Park, Heai-Ku (Faculty of Chemical & Materials Engineering, Keimyung University)
Lee, Chun-Soo (Faculty of Chemical & Materials Engineering, Keimyung University)
Cho, Bum-Rae (Faculty of Chemical & Materials Engineering, Keimyung University)
Byun, Hong-Sik (Faculty of Chemical & Materials Engineering, Keimyung University)
Choe, Seok-Burm (Faculty of Chemical & Materials Engineering, Keimyung University)
Suh, Seong-Il (Department of Microbiology, School of Medicine, Keimyung University)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.5, 2003 , pp. 623-626 More about this Journal
Abstract
Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.
Keywords
Xenorhabdus nematophilus; Staphylococcus aureus; Nematophin; Tryptamine; L-Isoleucine;
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