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http://dx.doi.org/10.5012/bkcs.2003.24.4.467

Convenient Synthesis of Optically Pure α-Mono and α,α-Disubstituted β-Amino Acids  

Lee, Hyun-Soo (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology)
Park, Jung-Dae (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology)
Kim, Dong-H. (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.4, 2003 , pp. 467-472 More about this Journal
Abstract
Optically pure α-mono- and α, α-disubstituted β-amino acids were conveniently prepared in four steps and in 27-40% overall yields from the correspondingly substituted racemic β-hydroxy acids that can be readily obtained from diethyl malonate. In the synthesis, (S)-phenylethylamine has been used as a resolving agent and as a source of the amino group in the β-amino acids.
Keywords
$\alpha$-Monosubstituted $\beta$-amino acids; $\alpha$,$\alpha$-Disubstituted $\beta$-amino acids; $\beta$-Lactams; (S)-Phenylethylamine;
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