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http://dx.doi.org/10.5012/bkcs.2003.24.11.1641

A New Approach to the Synthesis of Optically Active Norephedrine, Norpseudoephedrine and Cathinone via Double Asymmetric Induction  

Kim, Dong-Jun (Department of Chemistry, Hallym University)
Cho, Byung-Tae (Department of Chemistry, Hallym University)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.11, 2003 , pp. 1641-1648 More about this Journal
Abstract
New and facile synthetic routes for preparation of optically active norephedrine, norpseudoephedrine and cathinone with high optical purities via double asymmetric induction by employing asymmetric reduction of 2-N-protected amino (or azido)-1-phenylpropanone and 2-methanesulfonyloxy-1-phenylpropanone with CBS-catalyzed-borane and $^dIpc_2BCl$ as chiral reducing agents are described.
Keywords
Asymmetric reduction; Norephedrine; Norpsedorephedrine; Cathinone;
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