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http://dx.doi.org/10.5012/bkcs.2003.24.11.1637

Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences  

Lee, Jung-Hoon (School of Chemistry & Molecular Engineering, Seoul National University)
Lim, Yong-Beom (School of Chemistry & Molecular Engineering, Seoul National University)
Choi, Joon-Sig (School of Chemistry & Molecular Engineering, Seoul National University)
Choi, Myung-Un (School of Chemistry & Molecular Engineering, Seoul National University)
Yang, Chul-Hak (School of Chemistry & Molecular Engineering, Seoul National University)
Park, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.11, 2003 , pp. 1637-1640 More about this Journal
Abstract
Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.
Keywords
Gene delivery; PAMAM; Quaternary amine; Cytotoxicity;
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