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http://dx.doi.org/10.5012/bkcs.2002.23.3.454

Furo[3,2-h]quinoline Derivatives as a Gastric H+/K+-ATPase Inhibitors  

Kang, Seung-Kyu
Cho, Sung-Yun
Kim, Sung-Soo
Cheon, Hyae-Gyeong
Choi, Joong-Kwon
Yum, Eul-Kgun
Publication Information
Bulletin of the Korean Chemical Society / v.23, no.3, 2002 , pp. 454-458 More about this Journal
Abstract
Furo[3,2-h]quinoline derivatives were synthesized as a gastric $H^+$/$K^+$-ATPase inhibitors. The oxycyclization of 7 and 8-positions in quinoline potentiated the inhibitory activity, while no significant changes in biological activity were observed by the variation of substituents in furan ring. The several furo[3,2-h]quinoline derivatives were worthy of in vivo investigation for their anti-secretory and anti-ulcer activity.
Keywords
Furo[3,2-h]quinoline; Gastric $H^{+}/K^{+}$-ATPase inhibitors; Anti-secretory;
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