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http://dx.doi.org/10.5012/bkcs.2002.23.12.1709

Synthesis and Reactions of New Thienopyridines, Pyridothieniopyrimidines and Pyridothienotriazines  

Bakhite, E.A. (Chemistry Department, Faculty of Science, Assiut University)
Abdel Rahman, A.E. (Chemistry Department, Faculty of Science, Assiut University)
Mohamed, O.S. (Chemistry Department, Faculty of Science, Assiut University)
Thabet, E.A. (Chemistry Department, Faculty of Science, Assiut University)
Publication Information
Bulletin of the Korean Chemical Society / v.23, no.12, 2002 , pp. 1709-1714 More about this Journal
Abstract
4-Aryl-3-cyano-6-(2'-thienyl)-pyridine-2(1H)-thiones(1a-c) were reacted with phenacyl bromide, chloro-N-arylacetanmides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2'-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respecitively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.
Keywords
Thienopyridines; Pyrimidines; Triazines;
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