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http://dx.doi.org/10.17661/jkiiect.2022.15.5.396

Analysis of Anti-inflammatory Efficacy of Chrysanthemum coronarium PDRN (Polydeoxyribonucleotide)  

Song, Mi-Hee (Hyundaemedtech CO.Ltd)
Choi, Moon-Hyeok (Department of Electronic and Communication Engineering)
Jeong, Jin-Hyoung (Department of Biomedical IT)
Lee, Sang-Sik (Department of Biomedical Engineering, Catholic Kwandog University)
Jeong, Woo-Young (Department of Biomedical Science, Catholic Kwandog University)
Publication Information
The Journal of Korea Institute of Information, Electronics, and Communication Technology / v.15, no.5, 2022 , pp. 396-404 More about this Journal
Abstract
Chrysanthemum coronarium L. contains various antioxidants such as beta-carotene, vitamins A and C, and polyphenols, and is known to have anti-inflammatory effects. Under the assumption that the PDRN contained in the extract can mediate the anti-inflammatory response, the mouse macrophages, RAW264.7 cells, were stimulated with LPS to induce the conversion to inflammatory cells, and then the addition of PDRN extracted from the extract was effective in inhibiting inflammation. It was analyzed whether there was The gene expression of IL-1β and TNF-α was used as an anti-inflammatory index, and the relative expression levels of each gene were confirmed by RT-PCR. As a result, RT-PCR confirmed the effect of PDRN-induced inhibition of inflammation in both IL-1β and TNF-α genes. Therefore, based on this study, it is considered to be a precedent data that can be developed as a treatment for inflammatory diseases, and it will be helpful in research and development of a treatment that can improve the anti-inflammatory mechanism.
Keywords
$IL-1{\beta}$; RAW264.7; RT-PCR; $TNF-{\alpha}$; PDRN;
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