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http://dx.doi.org/10.9797/TSISS.2013.9.1.28

Fabrication and evaluation of label-free protein sensor for diagnosing acute myocardial infarction  

Cho, Younggeol (School of Mechanical Engineering, Yonsei Univ.)
Kang, Ki-Won (School of Mechanical Engineering, Yonsei Univ.)
Kim, Hyo-Kyum (School of Mechanical Engineering, Yonsei Univ.)
Cho, Eikhyun (School of Mechanical Engineering, Yonsei Univ.)
Kang, Shinill (School of Mechanical Engineering, Yonsei Univ.)
Publication Information
Transactions of the Society of Information Storage Systems / v.9, no.1, 2013 , pp. 28-31 More about this Journal
Abstract
We proposed a method to fabricate label-free protein sensor with sub-wavelength nanograting structures to be used for diagnosing acute myocardial infarction. A nickel stamp for the injection molding of nanograting integrated protein sensor was fabricated by electroforming process with high fidelity. By using metallic stamp, we replicated label-free protein sensor via injection molding, which is an outstanding method for low-cost and mass production of polymer products. Finally, we performed a feasibility test, examining cardiac troponin T (cTnT) and anti-cTnT interactions. From the results, we demonstrated that the fabricated protein sensor can provide information for the early and accurate detection of cardiac diseases such as acute myocardial infarction.
Keywords
Cardiac troponin T; label-free; protein sensor; injection molding; peak wavelength value;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Young Mi Hong, Byung-Kwan Lim, Jae-Ok Shin, and Eun-Seok Jeon, 2002, "Change of Serum Cardiac Troponin T and Fetal Troponin T Isoform in Rats with Adriamycin-induced Cardiac Injury", Korean Circulation J, Vol. 32, No. 6, pp.485-491   과학기술학회마을   DOI
2 Jay Huiyi Chua, Ru-Ern Chee, Ajay Agarwal, She Mein Wong, and Guo-Jun Zhang, 2009, "Label-free electrical detection of cardiac biomarker with complementary metal-oxide semiconductor-compatible silicon nanowire sensor arrays", Analytical Chemistry, Vol. 81, No. 15, pp.6266-6271   DOI   ScienceOn
3 Brian Cunningham, Peter Li, Bo Lin, and Jane Pepper, 2002, "Colorimetric resonant reflection as a direct biochemical assay technique", Sensors and Actuators B: Chemical, Vol. 81, No. 5, pp.316-328   DOI   ScienceOn
4 Bo Lin, Peter Li, and Brian T. Cunningham, 2005, "A label-free biosensor-based cell attachment assay for characterization of cell surface molecules", Sensors and Actuators B: Chemical, Vol. 114, pp.559-564
5 Shinill Kang et. al., 2011, "Design and fabrication of label-free biochip using a guided mode resonance filter with nano grating structures by injection molding process", Journal of Nanoscience and Nanotechnology, Vol. 11, No. 1, pp.417-421   DOI   ScienceOn