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Acute Toxicity Study on Taeeumjowi-tang in Mice  

Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Huang, Dae-Sun (Standard Research Division, Korea Institute of Oriental Medicine)
Seo, Chang-Seob (Standard Research Division, Korea Institute of Oriental Medicine)
Lee, Si-Woo (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Jong-Yeol (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine)
Shin, Hyeun-Kyoo (Standard Research Division, Korea Institute of Oriental Medicine)
Publication Information
Journal of Sasang Constitutional Medicine / v.22, no.2, 2010 , pp. 101-107 More about this Journal
Abstract
1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.
Keywords
Taeumjowi-tang(Taiyintiaowei-tang); Acute toxicity; Safety; LD50;
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Times Cited By KSCI : 8  (Citation Analysis)
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