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Acute Toxicity Study on Cheongsimyeonja-tang in Mice  

Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Huang, Dae-Sun (Standard Research Division, Korea Institute of Oriental Medicine)
Seo, Chang-Seob (Standard Research Division, Korea Institute of Oriental Medicine)
Lee, Si-Woo (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Jong-Yeol (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine)
Shin, Hyeun-Kyoo (Standard Research Division, Korea Institute of Oriental Medicine)
Publication Information
Journal of Sasang Constitutional Medicine / v.22, no.1, 2010 , pp. 59-65 More about this Journal
Abstract
1. Objectives: The aim of this study is data analysis for acute toxicity and safety of Cheongsimyeonja-tang. 2. Methods: We investigated the acute toxicity for water-extracted Cheongsimyeonja-tang. Fifty five male and female mice were observed for 14 days after one day oral administration of Cheongsimyeonja-tang at the respective doses of 0 (control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. In animals administered with Cheongsimyeonja-tang, there were nither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign and autopsy. 4. Conclusion: The data confirmed that Cheongsimyeonja-tang is free from the toxicity and safety problems in treated groups. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). Lethal Dose 50 (LD50) value for mice was more than 5000 mg/kg per oral for both male and females. It suggest that Cheongsimyeonja-tang in mice is considered to be safe.
Keywords
Cheongsimyeonja-tang(Qingxinlianzi-tang); Acute Toxicity; Toxicity Test; LD50;
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Times Cited By KSCI : 16  (Citation Analysis)
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1 Ma JY, Yu YB, Ha HK, Huang DS, Shin HK. Subacute toxicity study of Sagunja-tang(sijunzi-tang) in SD rats. Kor J Oriental Med. 2007;13(3):151-156. (Korean)   과학기술학회마을
2 Ma JY, Yu YB, Ha HK, Huang DS, Shin HK. Subacute toxicity study on Palmultang(Bawu-Tang) in SD rats. Kor J Herbology. 2007;22(4):59-64. (Korean)   과학기술학회마을
3 Ma JY, Huang DS, Lee SW, Kim JY, Shin HK. Acute toxicity study on Yeoldahanso-tang in mice. J of Sasang Constitutional Med. 2009;21(1):247-253. (Korean)   과학기술학회마을
4 Ma JY, Yu YB, Ha HK, Huang DS, Ma CJ, Shin HK. Acute toxicity study on Samul-tang(Siwu-tang) in mice. Kor J Oriental Medical Prescription. 2007;15(2):113-117. (Korean)   과학기술학회마을
5 Ma JY, Huang DS, Lee NH, Ha HK, Yu YB, Shin HK. Acute toxicity study on Sipjeondaebo-tang in rats. Kor J Oriental Physiology and Pathology. 2008;22(5): 1192-1195. (Korean)   과학기술학회마을
6 Kim HS, Bae YC, Lee SM, Kim KY. A study of the effects of Cheongsimyeonjatang(CYT) on ECG in comparing before and after CYT medication. J of Sasang Constitutional Med. 2003;15(3):147-157. (Korean)   과학기술학회마을
7 Ma JY, Huang DS, Yu YB, Ha HK, Shin HK. Acute toxicity study on Palmul-tang(Bawu-tang) in mice. Kor J Herbology. 2007;22(2):13-16. (Korean)   과학기술학회마을
8 Yoon YK, Sun TC, Jang HJ, Song WS. A clinical case of liver injury induced by Chungsim Yeonja-tang. J Oriental Internal Med. 2004;25(3):539-544. (Korean)   과학기술학회마을
9 Mun BH, Kim JG. A case study of hepatitis on drug metabolism improved with Chungsimyeunjatang. J of Sasang Constitutional Med. 2003;15(1):129-132. (Korean)   과학기술학회마을
10 Park SC. Effects CheongSimYeonJaTang(CSYJT) on control of immune-function in highly purified mouse B cells and mast cell. J of Sasang Constitutional Med. 2003;15(2):166-179. (Korean)   과학기술학회마을
11 Noh HS, Kim KS. Studies on the regulatory effect of cytokine production in Taeumin patients with cerebral infarction by Cheongsimyeonjatang. J of Sasang Constitutional Med. 2000;12(2):162-170. (Korean)
12 Lee JM. Donguisusebowon. Seoul:Yeogang Publishing Co. 1992:271-272. (Korean)
13 Lee JH, Kim HS, Bae YC, Kim KY, Won KS, Hwang SY. Effects of Cheongsimyeonja-tang water extract on the cultured primary hippocampal cell damaged by XO/HX. J of Sasang Constitutional Med. 2002;14(3): 132-145. (Korean)   과학기술학회마을
14 Yoon HD, Shin OC, Shin YJ, Park CS, Kim SM. Effect of Chungsimyeonjatang on myocardiac cell injury in mouse myoblast C2C12 cells. J Kor Oriental Internal Med. 2007;28(2):333-345. (Korean)   과학기술학회마을
15 Kim HS, Bae YC, Lee SM, Kim KY. A study of the effects of Cheongsimyeonjatang (CYT) on ECG in comparing before and after CYT medication: case study of hospitalized Taeumin patients. J of Sasang Constitutional Med. 2003;15(3):147-157. (Korean)   과학기술학회마을
16 Lim JP, Ahn TK. The anti-oxidative and immuneregulatory effect of Chungsimyeonja-tang in aged rat. J of Sasang Constitutional Med. 2007;19(3):227-241. (Korean)   과학기술학회마을
17 Kim JC, Oh SW, Song CH, Lee SH, Jeong JJ, Kim JY, et al. Case report of Chengsim Yeunja-tang (CYT) for atrial fibrillation with cerebral-infarction. J Kor Oriental Internal Med. 2006;27(3):751-761. (Korean)   과학기술학회마을
18 Hwang SY, Lee JH, Kim HS, Bae YC, Kim KY, Won KS. Effects of Cheongsimyeonja-tang water extract on the cultured primary hippocampal cell damage by XO/HX. J of Sasang Constitutional Med. 2002;14(3): 132-145. (Korean)   과학기술학회마을