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http://dx.doi.org/10.46670/JSST.2021.30.3.185

AgNW-based functional polymer cantilever to improve maturity and contractility of cardiomyocytes  

Jeung, Min-young (Graduate School of Mechanical Engineering, Chonnam National University)
Sim, Yu-ri (Graduate School of Mechanical Engineering, Chonnam National University)
Yun, Ha-young (Graduate School of Mechanical Engineering, Chonnam National University)
Kim, Dong-Su (Graduate School of Mechanical Engineering, Chonnam National University)
Lee, Dong-Weon (Graduate School of Mechanical Engineering, Chonnam National University)
Publication Information
Journal of Sensor Science and Technology / v.30, no.3, 2021 , pp. 185-189 More about this Journal
Abstract
Herein, we propose a functional polymer cantilever to enhance maturation and contractile force of cardiomyocytes. The proposed cantilever consists of a surface-patterned polymer substrate and silver nanowires (AgNWs). The AgNWs are transferred to the PDMS substrate using conventional molding techniques. This thin metallic surface significantly improves the adhesion of cardiomyocyte on the surface-patterned PDMS with the hydrophobic characteristics. In addition, the use of AgNWs improves the visibility of the conducting PDMS substrate for the observation of cardiomyocyte through an inverted microscope. The AgNWs also assist in synchronizing each cardiomyocyte to maximize its contractile force.
Keywords
Functional polymer cantilever; Ag nano-wires; Micro grooves; Cardiomyocytes; Contraction force;
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