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http://dx.doi.org/10.5369/JSST.2018.27.3.170

Fabrication and Improved Sensitivity with Surface Treatment of TiO2/GOD Mixture based Glucose Biosensor  

Lee, Junyeop (School of Electronics Engineering, Kyungpook National University)
Jung, Dong Geon (School of Electronics Engineering, Kyungpook National University)
Lee, Jae Yong (School of Electronics Engineering, Kyungpook National University)
Kim, Jae Keon (Aircraft System Technology Group, Korea Institute of Industrial Technology)
Jung, Daewoong (Aircraft System Technology Group, Korea Institute of Industrial Technology)
Kong, Seong Ho (School of Electronics Engineering, Kyungpook National University)
Publication Information
Journal of Sensor Science and Technology / v.27, no.3, 2018 , pp. 170-174 More about this Journal
Abstract
In this paper, the $TiO_2$/glucose oxidase (GOD) mixture has synthesized through simple and low-cost fabrication methods. The physical properties of the mixture were proved using an FT-IR/NIR spectrometer, an X-Ray diffractometer, and a Raman spectrometer. GOD maintained its bioactivity during all fabrication process. The current characteristics of the glucose biosensor were proportional to the glucose concentration and effective surface area of square pyramid on a silicon substrate. The maximum current change was measured in a pH 7.0 buffer solution. The simple and low-cost fabrication process and surface treatment can be used widely in previous research for improvements in effective surface area.
Keywords
Glucose biosensor; Glucose oxidase (GOD); Titanium dioxide ($TiO_2$); Surface treatment; Micro Electro Mechanical Systems (MEMS);
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  • Reference
1 L Gorton, "Carbon paste electrodes modified with enzymes, tissues, and cells", Electroanalysis, Vol. 7(1), pp. 23-45, 1995.   DOI
2 P. N. Bartlett, P. Tebbutt, and R. G. Whitaker, Kinetic aspects of the use of modified electrodes and mediators in bioelectrochemistry, Pergamon Press, New York, pp. 1-101, 1991.
3 M. Viticoli, A. Curulli, A. Cusma, S. Nunziante, L. Pandolfi, F. Valentini, and G. Padeletti, "Third-generation biosensors based on TiO2 nanostructured films", Mater. Sci. Eng. C, Vol. 26(5-7), pp. 947-951, 2006.   DOI
4 E. Topoglidis, A. E. G. Cass, G. Gilardi, S. Sadeghi, N. Beaumont, and J. R. Durrant, "Protein Adsorption on Nanocrystalline $TiO_2$ Films: An Immobilization Strategy for Bioanalytical Devices", Anal. Chem., Vol. 70(23), pp. 5111-5113, 1998.   DOI
5 J. Wang, "Electrochemical glucose biosensors", Chem. Rev., Vol.108(2), pp. 814-825, 2007.   DOI
6 A. Heller, "Electrical connection of enzyme redox centers to electrodes", J. Phys. Chem., Vol. 96(9), pp. 3578-3587, 1992.