Browse > Article
http://dx.doi.org/10.5369/JSST.2014.23.6.409

Development of Inductive and Capacitive Type Intraocular Pressure (IOP) Sensor to Improve Sensitivity and Minimize Size  

Jang, Cheol In (Center for Biomicrosystems, Korea Institute of Science and Technology (KIST))
Shin, Kyeong-Sik (Center for Biomicrosystems, Korea Institute of Science and Technology (KIST))
Yun, Kwang-Seok (Department of Electronic Engineering, Sogang University)
Kim, Yong Woo (Department of Ophthalmology, Seoul National University Hospital)
Kang, Ji Yoon (Center for Biomicrosystems, Korea Institute of Science and Technology (KIST))
Lee, Soo Hyun (Center for Biomicrosystems, Korea Institute of Science and Technology (KIST))
Publication Information
Journal of Sensor Science and Technology / v.23, no.6, 2014 , pp. 409-415 More about this Journal
Abstract
We had presented an inductive type intraocular pressure sensor (L-sensor) in previous work. The distance between a micro coil and a ferrite on the membrane was modulated by pressure, and as a result the inductance and resonant frequency were changed. However, L-sensor has some problems to implant in eyes. First problem is low sensitivity. When L-sensor was implanted in rabbit's eyes, resonant frequency of L-sensor was very hard to detect. Second problem is biocompatibility. Size of L-sensor is $6{\times}7{\times}1.2mm$. When L-sensor was implanted in the eyes, it caused the inflammation. Therefore, this study suggests an inductive and capacitive type IOP sensor (LCsensor). The sensitivity of the LC-sensor 27.3 kHz/mmHg under 60mmHg. It is much larger than 14 kHz/mmHg of the L-sensor. And the size of LC-sensor is 47% smaller than L-sensor. After 2 weeks from the implantation of LC-sensor into rabbit eyes, we measured the changes of resonant frequency of LC-sensor according to increased IOP by Balanced Salt Solution (BSS) injection. As a result, the sensitivity of LC-sensor in in vivo test is 25 kHz/mmHg. That is similar to the sensitivity of in vitro test.
Keywords
Glaucoma; Intraocular pressure (IOP); IOP sensor; in vivo; Wireless; Implantable;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 M. Sherwood, Glaucoma, in Ophthalmology, 2nd ed. M. Yanoff and J. S. Duker, Eds. St. Louis, MO: Mosby," pp. 1413-1473, 2004.
2 H. A. Q. a. A. T. Broman, "The number of people with glaucoma worldwide in 2010 and 2020", Br. J. Ophthalmol, Vol. 90, No. 3, pp. 262-267, 2006.   DOI   ScienceOn
3 R. E. P. Frenkel, Y. J. Hong, and D. H. Shin, "Comparison of the tono-pen to the goldmann applanation tonometer", Arch Ophthalmol, pp. 750-753, 1988.
4 R. Puers, G. Vandevoorde, and D. D. Bruyker, "Electrodeposited copper inductors for intraocular pressure telemetry", J Micromech Microeng, Vol. 10, p. 124, 2000.   DOI
5 E. Schneider and F. Grehn, "Intraocular pressure measurement-comparison of dynamic contour tonometry and goldmann applanation tonometry", J Glaucoma, Vol. 15, pp. 2-6, 2006.   DOI   ScienceOn
6 F. A. a. J. M. D. Albert D M, Principles and Practice of Ophthalmology (Philadelphia, PA: W.B. Saunders Company), 1994.
7 R. W. S. Harold G. Scheie, and Ernest D. Helmick, "Tonography in the clinical management of glaucoma", Trans Am Ophthalmol Soc, Vol. 53, pp. 265-299, 1955.
8 G. Z. Chen, I. S. Chan, and D. C. C. Lam, "Capacitive contact lens sensor for continuous non-invasive intraocular pressure monitoring", Sens. Actuator A-Phys., Vol. 203, pp. 112-118, 2013.   DOI
9 T. Chien-Kai, H. Yu-Chieh, T. Shang-Wei, Y. Guan-Ting, C. Chung-Hao, and C. Jin-Chern, "Design and fabricate a contact lens sensor with a micro-inductor embedded for intraocular pressure monitoring", in Sensors, 2012 IEEE, 2012, pp. 1-4.
10 M. Leonardi, "Wireless contact lens sensor for intraocular pressure monitoring: assessment on enucleated pig eyes", Acta Ophthalmologica, Vol. 87, pp. 433-437, 2009.   DOI
11 H. Yu-Chieh, Y. Guan-Ting, Y. Tzu-Sen, and C. Jin-Chern, "A contact lens sensor system with a micro-capacitor for wireless intraocular pressure monitoring", in Sensors, 2013 IEEE, pp. 1-4, 2013.
12 G. Chitnis, T. Maleki, B. Samuels, L. B. Cantor, and B. Ziaie, "A minimally invasive implantable wireless pressure sensor for continuous IOP monitoring", IEEE T Bio-Med Eng, Vol. 60, pp. 250-256, 2013.   DOI
13 C. Po-Jui, C. R. Damien, A. Rajat, S. Saloomeh, M. Ellis, V. Rohit, et al., "Implantable micromechanical parylenebased pressure sensors for unpowered intraocular pressure sensing", J Micromech Microeng, Vol. 17, p. 1931, 2007.   DOI
14 C. Po-Jui, D. C. Rodger, S. Saati, M. S. Humayun, and T. Yu-chong, "Implantable parylene-based wireless intraocular pressure sensor", in Micro Electro Mechanical Systems, 2008. MEMS 2008. IEEE 21st International Conference on, 2008, pp. 58-61.
15 C. Po-Jui, S. Saati, R. Varma, M. S. Humayun, and T. Yuchong, "Wireless intraocular pressure sensing using microfabricated minimally invasive flexible-coiled LC sensor implant", J. Microelectromech. Syst, Vol. 19, pp. 721-734, 2010.   DOI
16 I. K. Lee, S. S. Kim, J. C. Jang, K. J. Kim, K. A. Kim, T. S. Lee, and E. J. Cha, "Wearable wireless respiratory monitoring system", J. Sensor Sci & Tech, Vol. 17, No. 2, pp. 133-142, 2008.   DOI
17 S. H. Cho, S. H. Son, H. J. Chung, and J. B. Lee, "A wireless powered fully integrated SU-8-based implantable LC transponder", Microsyst Technol, Vol. 16, pp. 1657-1663, 2010.   DOI
18 K. Byungjoo, H. Hoyong, L. Soo Hyun, K. Jiyoon, P. Jounghu, S. Chulhum, et al., "A wireless intraocular pressure sensor with variable inductance using a ferrite material", J Semicond Tech SCI, Vol. 13, pp. 355-360, 8 2013.   DOI
19 X. Ning, C. Sung-Pil, and L. Jeong-Bong, "A SU-8-based microfabricated implantable inductively coupled passive RF wireless intraocular pressure sensor", J. Microelectromech. Syst, Vol. 21, pp. 1338-1346, 2012.   DOI
20 D. S. Kang and W. K. Moon, "Micro-machined capacitive linear encoder with a mechanical guide", J. Sensor Sci & Tech, Vol. 21, No. 6, pp. 440-445, 2012.   DOI
21 J. C. H. Lin, Z. Yu, C. Po-Jui, and T. Yu-chong, "High quality factor parylene-based intraocular pressure sensor", in Nano/Micro Engineered and Molecular Systems (NEMS), 2012 7th IEEE International Conference on, 2012, pp. 137-140, 2012.
22 O. Akar, T. Akin, and K. Najafi, "A wireless batch sealed absolute capacitive pressure sensor", Sens. Actuator APhys., Vol. 95, pp. 29-38, 2001.   DOI
23 T. H. Lee, The Design of CMOS Radio-frequency Integrated Circuits, 2nd ed. Cambridge, UK ; New York: Cambridge University Press, 2004.