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http://dx.doi.org/10.5369/JSST.2013.22.4.281

Development of Sugar Sensitive Drosophila Cell based ISFET Sensor for Alzheimer's Disease Diagnosis  

Lim, Jeong-Ok (Biomedical Research Institute, Kyungpook National University)
Yu, Joon-Boo (Materials Science and Metallurgical Engineering, Kyungpook National University)
Kwon, Jae-Young (Biological Science, Sungkyunkwan University)
Byun, Hyung-Gi (Department of Information and Communication Engineering, Kangwon Naltional University)
Huh, Jeung-Soo (Materials Science and Metallurgical Engineering, Kyungpook National University)
Cho, Won-Ju (Department of Electronic Material Engineering, Kwangwoon Uinversity)
Publication Information
Journal of Sensor Science and Technology / v.22, no.4, 2013 , pp. 281-285 More about this Journal
Abstract
In this study a biosensor was developed by using Drosophila cells expressing a gustatory receptor Gr5a and an ion sensitive field effect transistors (ISFETs) sensor device, which demonstrated significant compatibility with the Drosophila cells expressing Gr5a and their response to sugar. These results suggested that the newly developed cell based biosensor has a potential as a simple and easy screening device for Alzheimer's disease in the future.
Keywords
Alzheimer's disease (AD); Non-invasive sampling; Sugars as AD biomarker candidate; Cell based biosensor; Drosophila; ISFET; Medical diagnostic device;
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