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http://dx.doi.org/10.14776/piv.2018.25.e8

Changes in Cytomegalovirus Seroprevalence in Korea for 21 Years: a Single Center Study  

Choi, Sae Rom (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Kyung-Ran (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Dong Sub (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kang, Ji-Man (Department of Pediatrics, National Cancer Center)
Kim, Sun Ja (Department of Pediatrics, Cheju Halla General Hospital)
Kim, Jong Min (Department of Pediatrics, Myungji Hospital)
Oh, Soo-young (Department of Gynecology and Obstetrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kang, Choel-In (Department of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Chung, Doo Ryeon (Department of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Peck, Kyong Ran (Department of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kang, Eun-Suk (Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Yae-Jean (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Pediatric Infection and Vaccine / v.25, no.3, 2018 , pp. 123-131 More about this Journal
Abstract
Purpose: Cytomegalovirus (CMV) infection is mostly asymptomatic but can be detrimental to certain hosts. We investigated changes of CMV seroprevalence in Koreans before and after the year 2000. Methods: We reviewed laboratory values of patients who were tested for CMV immunoglobulin G (IgG) at Samsung Medical Center, Seoul, Korea, from January 1995 to December 2015. Changes in seroprevalence were analyzed by gender, age, region, and tested year period (period 1, 1995-2005 vs. period 2, 2006-2015). Results: Overall CMV seropositivity was 94.1% (10,900/11,584). There was no significant difference for CMV seropositivity among the two periods (94.2% vs. 94.1%) (P=0.862). CMV seropositivity in the 11 to 20-year age group in period 2 (78.8%) was significantly lower than that of period 1 (89.9%) (P=0.001). The seropositivity of individuals aged 31-40 years (97.4%) was significantly higher than that of younger age groups (P<0.001) and lower than that of older age groups (P<0.001). Of 2,441 females of reproductive age (from 15 to 49), CMV seropositivity was 97% (2,467/2,441). The seropositivity in women aged 20-24-years was higher than that of men in the same age group (97.6% vs. 85.6%, P=0.003). No significant difference was observed among different regions. Conclusions: Overall CMV seropositivity of Koreans was estimated to be 94% and the average seropositivity of reproductive women was 97%. Monitoring of the changes in seroprevalence including the reproductive age group is needed in the future.
Keywords
Cytomegalovirus; Seroprevalence; Korea;
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