Browse > Article
http://dx.doi.org/10.14776/piv.2018.25.1.45

Late-Onset Group B Streptococcal Meningitis Complicated with Extensive Cerebral Infarction  

Cho, Min Su (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
Kim, Yongmin (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
Cho, Hye-Kyung (Department of Pediatrics, Gil Medical Center, Gachon University College of Medicine)
Choi, Soo-Han (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
Publication Information
Pediatric Infection and Vaccine / v.25, no.1, 2018 , pp. 45-49 More about this Journal
Abstract
Group B streptococcus (GBS) is the leading cause of neonatal morbidity and mortality. Late-onset GBS disease commonly manifests as occult bacteremia or meningitis. Approximately 50% of survivors of late-onset meningitis have long-term neurologic sequelae. Cerebrovascular complications are often associated with unfavorable clinical outcomes of GBS meningitis. There have been a few reports of cerebral infarction accompanied by GBS meningitis. We report a 29-day-old girl with severe, widespread cerebral infarction due to late-onset GBS meningitis. Isolated GBS strain from this patient was serotype III, ST-19. Currently, she has cortical blindness and significant developmental delay.
Keywords
Streptococcus agalactiae; Neonatal sepsis; Meningitis; Cerebral infarction;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Pannaraj PS, Baker CJ. Group B streptococcal infections. In: Cherry JD, Demmler-Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry's Textbook of pediatric infectious diseases. 7th ed. Philadelphia: Saunders Elsevier, 2014:1153-69.
2 Lachenauer CS, Wessels MR. Group B streptococcus. In: Kliegman RM, Nelson WE, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier, 2016:1337-41.
3 Hernandez MI, Sandoval CC, Tapia JL, Mesa T, Escobar R, Huete I, et al. Stroke patterns in neonatal group B streptococcal meningitis. Pediatr Neurol 2011;44:282-8.   DOI
4 deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, et al. Epidemiology and outcomes of arterial ischemic stroke in children: the Canadian Pediatric Ischemic Stroke Registry. Pediatr Neurol 2017;69:58-70.   DOI
5 Pryde K, Walker WT, Hollingsworth C, Haywood P, Baird J, Hussey M, et al. Stroke in paediatric pneumococcal meningitis: a cross-sectional population-based study. Arch Dis Child 2013;98:647-9.   DOI
6 Lehman LL, Rivkin MJ. Perinatal arterial ischemic stroke: presentation, risk factors, evaluation, and outcome. Pediatr Neurol 2014;51:760-8.   DOI
7 Cho HK, Nam HN, Cho HJ, Son DW, Cho YK, Seo YH, et al. Serotype distribution of invasive group B streptococcal diseases in infants at two university hospitals in Korea. Pediatr Infect Vaccine 2017;24:79-86.
8 Jones N, Bohnsack JF, Takahashi S, Oliver KA, Chan MS, Kunst F, et al. Multilocus sequence typing system for group B streptococcus. J Clin Microbiol 2003;41:2530-6.   DOI
9 Cho HK, Lee H, Kang JH, Kim KN, Kim DS, Kim YK, et al. The causative organisms of bacterial meningitis in Korean children in 1996-2005. J Korean Med Sci 2010;25:895-9.   DOI
10 Pintye J, Saltzman B, Wolf E, Crowell CS. Risk factors for late-onset group B streptococcal disease before and after implementation of universal screening and intrapartum antibiotic prophylaxis. J Pediatric Infect Dis Soc 2016;5:431-8.   DOI
11 Chong Y, Lee K, Kwon OH, Nahm CH, Murai T, Inazumi Y. Trend of isolation and serotypes of group B streptococci in Korea. Yonsei Med J 1993;34:78-83.   DOI
12 Uh Y, Jang IH, Yoon KJ, Lee CH, Kwon JY, Kim MC. Colonization rates and serotypes of group B streptococci isolated from pregnant women in a Korean tertiary hospital. Eur J Clin Microbiol Infect Dis 1997;16:753-6.   DOI
13 Hong JS, Choi CW, Park KU, Kim SN, Lee HJ, Lee HR, et al. Genital group B Streptococcus carrier rate and serotype distribution in Korean pregnant women: implications for group B streptococcal disease in Korean neonates. J Perinat Med 2010;38:373-7.
14 Lee BK, Song YR, Kim MY, Yang JH, Shin JH, Seo YS, et al. Epidemiology of group B streptococcus in Korean pregnant women. Epidemiol Infect 2010;138:292-8.   DOI
15 Park KH, Kim KH, Kang JH, Kim KN, Kim DS, Kim YK, et al. Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea. Pediatr Int 2011;53:236-9.   DOI
16 Tibussek D, Sinclair A, Yau I, Teatero S, Fittipaldi N, Richardson SE, et al. Late-onset group B streptococcal meningitis has cerebrovascular complications. J Pediatr 2015;166:1187-92.e1.   DOI
17 Boelman C, Shroff M, Yau I, Bjornson B, Richrdson S, deVeber G, et al. Antithrombotic therapy for secondary stroke prevention in bacterial meningitis in children. J Pediatr 2014;165:799-806.   DOI
18 Chang CJ, Chang WN, Huang LT, Chang YC, Huang SC, Hung PL, et al. Cerebral infarction in perinatal and childhood bacterial meningitis. QJM 2003;96:755-62.   DOI
19 Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, et al. The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates. J Exp Med 2010;207:2313-22.   DOI
20 Kang HM, Lee HJ, Lee H, Jo DS, Lee HS, Kim TS, et al. Genotype characterization of group B streptococcus isolated from infants with invasive diseases in South Korea. Pediatr Infect Dis J 2017;36:e242-7.   DOI