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http://dx.doi.org/10.14776/piv.2017.24.2.79

Serotype Distribution of Invasive Group B Streptococcal Diseases in Infants at Two University Hospitals in Korea  

Cho, Hye-Kyung (Department of Pediatrics, Gachon University College of Medicine)
Nam, Hye Na (Department of Pediatrics, Gachon University College of Medicine)
Cho, Hye Jung (Department of Pediatrics, Gachon University College of Medicine)
Son, Dong Woo (Department of Pediatrics, Gachon University College of Medicine)
Cho, Yong Kyun (Division of Infection, Department of Internal Medicine, Gachon University College of Medicine)
Seo, Yiel-Hea (Department of Laboratory Medicine, Gachon University College of Medicine)
Kim, Yae-Jean (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Eun, Byung Wook (Department of Pediatrics, Nowon Eulji Medical Center, Eulji University School of Medicine)
Publication Information
Pediatric Infection and Vaccine / v.24, no.2, 2017 , pp. 79-86 More about this Journal
Abstract
Purpose: This study was aimed at analyzing the serotypes of group B streptococcus (GBS) isolated from Korean infants with invasive disease and evaluating their association with disease manifestation. Methods: Data were retrospectively collected from invasive GBS infections at Gachon University Gil Medical Center from January 2006 to June 2012 and at Samsung Medical Center from April 2010 to November 2012. Serotypes were determined by slide agglutination test. Results: A total of 37 cases were identified, which included 22 full-term infants and 15 preterm infants. Fifteen cases (40.5%) were early-onset, 19 (51.4%) was late-onset, and three (8.1%) was very late-onset. Early-onset diseases among preterm infants were higher than those among full-term infants (60.0% [9/15] vs. 27.3% [6/22], P=0.17). The most common manifestation was bacteremia (70.3%), followed by meningitis and septic arthritis. Among 24 isolates retrievable for serotyping, serotype III (41.7%) was most common, followed by V (16.7%), Ia, Ib, and II (12.5%, respectively), and non-typeable (4.2%). Serotype III was more common in isolates from full-term infants (10/22) than from preterm infants (0/15), whereas serotype V was more common in isolates from preterm infants (4/15) than from full-term infants (0/22) (P=0.002). No penicillin-resistant strain was detected, and resistance to erythromycin and clindamycin were both 64.9%. Conclusions: GBS is an important pathogen in both preterm and full-term infants, and serotype distribution of GBS causing invasive diseases can differ between preterm and full-term infants. It is necessary to monitor the nationwide epidemiology of GBS diseases, including in preterm infants, in order to prepare preventive measures without underestimating early-onset diseases.
Keywords
Streptococcus agalactiae; Infant; Infant, newborn;
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