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http://dx.doi.org/10.14776/piv.2016.23.1.46

Epidemiology and Clinical manifestations of Enterovirus in Pediatric Inpatient in Incheon  

Cho, Byoung Wook (Department of Pediatrics, Inha University School of Medicine)
Kwon, Seong Eun (Department of Pediatrics, Inha University School of Medicine)
Kwon, Mun Ju (Incheon Research Institute of Public Health and Environment)
Hur, Myong Je (Incheon Research Institute of Public Health and Environment)
Kim, Kyung Seon (Incheon Research Institute of Public Health and Environment)
Hong, Young Jin (Department of Pediatrics, Inha University School of Medicine)
Kim, Soon Ki (Department of Pediatrics, Inha University School of Medicine)
Kwon, Young Se (Department of Pediatrics, Inha University School of Medicine)
Kim, Dong Hyun (Department of Pediatrics, Inha University School of Medicine)
Publication Information
Pediatric Infection and Vaccine / v.23, no.1, 2016 , pp. 46-53 More about this Journal
Abstract
Purpose: Enterovirus (EV) infection in children can manifest various diseases from asymptomatic infection to nonspecific febrile illness, hand-foot-mouth disease, and aseptic meningitis. This study was aimed to investigate epidemiology and clinical significance of various genotypes of EV infections in pediatric inpatient. Methods: We collected the stool samples from the admitted pediatric patients in Inha University Hospital from March 2014 to March 2015. EV detection and genotype identification were performed by real-time RT-PCR and semi-nested RT-PCR. Phylogenetic trees were constructed by neighbor joining method. Results: A total of 400 samples were collected during study period and 112 patients (28%) were diagnosed with EV infections. The mean age of EV positive patients was 2.66 years (0.1-14) and sex ratio was 1.73:1. Genetic sequences of EVs were identified; coxsackievirus B5 (17, 15.2%), coxsackievirus A16 (13, 11.6%), enterovirus 71 (10, 8.9%), and coxsackievirus A2 (9, 8.0%). Nonspecific febrile illness (96, 86%) was the most common clinical manifestation and the duration of fever was 0-11 days (mean 3.1 days). Rash (44, 39%) and meningitis (43, 38%) were followed. Patients who were attending daycare center or had siblings accounted for 82.1%. Phylogenetic relationship tree revealed 6 distinct genogroups among 56 types of EVs. Conclusions: This study is the report of epidemiology, serotype distribution and clinical manifestations of children with EV infection in Incheon. This data will be helpful for further study about the epidemiology of EV infection in Korea.
Keywords
Enterovirus; Epidemiology; Children; Genotype;
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