Browse > Article
http://dx.doi.org/10.14776/piv.2015.22.2.117

A Case of Acute Idiopathic Thrombocytopenic Purpura Following Influenza B Virus Infection  

Jung, Seungwon (Department of Pediatrics, The Catholic University of Korea College of Medicine)
Kang, Sunghee (Department of Pediatrics, The Catholic University of Korea College of Medicine)
Kang, Jin Han (Department of Pediatrics, The Catholic University of Korea College of Medicine)
Ma, Sang Hyuk (Department of Pediatrics, Fatima Hospital)
Publication Information
Pediatric Infection and Vaccine / v.22, no.2, 2015 , pp. 117-120 More about this Journal
Abstract
Virus-associated immune thrombocytopenic purpura (ITP) can occur following common viruses, but cases of ITP associated with influenza infection has seldom been reported. In this report we describe a previously healthy 5-year-old boy who admitted with fever, flu-like symptoms and a few bruises on both legs. Severe thrombocytopenia were found. Bone marrow aspirates and biopsy showed no abnormalities and results of coagulation tests were all in normal limit. Real-time polymerase chain reaction was positive for influenza B infection. The patient fully recovered with intravenous immunoglobulins and steroid therapy.
Keywords
Idiopathic thrombocytopenic purpura; Influenza;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Scott JP, Montgomery RR. Platelet and blood vessel disorder. In: Kligeman RM, Stanton BF, St.Geme JW, Schor NF, Berhman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: WB Saunders Elsevier, 2011:1714-7.
2 Yenicesu I, Yetgin S, Ozyurek E, Aslan D. Virus-associated immune thrombocytopenic purpura in childhood. Pediatr Hematol Oncol 2002;19:433-7.   DOI
3 Shizuma T. Immune thrombocytopenia following influenza virus infection and influenza vaccine administration. Virol Mycol 2014;S2:003.
4 Rice J, Resar LM. Hematologic abnormalities associated with influenza A infection: a report of 3 cases. Am J Med Sci 1998;316:401-3.   DOI
5 Wolf DG, Greenberg D, Kalkstein D, Shemer-Avni Y, Givon-Lavi N, Saleh N, et al. Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J 2006;25:320-4.   DOI
6 Nichols JE, Niles JA, Roberts NJ Jr. Human lymphocyte apoptosis after exposure to influenza A virus. Virol 2001;75:5921-9.   DOI
7 Hinshaw VS, Olsen CW, Dybdahl-Sissoko N, Evans DJ. Apoptosis: a mechanism of cell killing by influenza A and B viruses. Virol 1994;68:3667-73.
8 Sedger LM, Hou S, Osvath SR, Glaccum MB, Peschon JJ, van Rooijen N, et al. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 2002;169:6193-201.   DOI
9 Wang CC, Chen PY, Wang JD, Liu FC, Huang FL, Lee CY. Clinical and laboratory analysis of influenza B infection in children in Taichung, Taiwan during the 2006-2007 flu season. Pediatr Neonatol 2009;50:54-8.   DOI
10 Ikegame K, Kaida K, Fujioka T, Kawakami M, Hasei H, Inoue T, et al. Idiopathic thrombocytopenic purpura after influenza vaccination in a bone marrow transplantation recipient. Bone Marrow Transplant 2006;38:323-4.   DOI
11 Tishler M, Levy O, Amit-Vazina M. Immune thrombocytopenic purpura following influenza vaccination. Isr Med Assoc J 2006;8:322-3.
12 Mantadakis E, Farmaki E, Thomaidis S, Tsalkidis A, Chatzimichael A. A case of immune thrombocytopenic purpura after influenza vaccination: consequence or coincidence? J Pediatr Hematol Oncol 2010;32:e227-9.   DOI
13 Casoli P, Tumiati B. Acute idiopathic thrombocytopenic purpura after anti-influenza vaccination. Medicina 1989;9:417-8.
14 Montagnani S, Tuccori M, Lombardo G, Testi A, Mantarro S, Ruggiero E, et al. Autoimmune hemolytic anemia following MF59-adjuvanted influenza vaccine administration: a report of two cases. Ann Pharmacother 2011;45:e8.   DOI
15 Scott S, Reimers HJ, Chernesky MA, Greenberg JP, Kinolugh-Rathbone RL, Packham MA, et al. Effect of viruses on platelet aggregation and platelet survival in rabbits. Blood 1978;52:47-55.
16 Lee CY, Wu MC, Chen PY, Chou TY, Chan YJ. Acute immune thrombocytopenic purpura in an adolescent with 2009 novel H1N1 influenza A virus infection. J Chin Med Assoc 2011;74:425-7.   DOI
17 Kaneko H, Ohkawara Y, Nomura K, Horiike S, Taniwaki M. Relapse of idiopathic thrombocytopenic purpura caused by influenza A virus infection: a case report. J Infect Chemother 2004;10:364-6.   DOI