Browse > Article
http://dx.doi.org/10.14776/kjpid.2014.21.1.65

Congenital Syphilis: An Uncommon Cause of Gross Hematuria, Skin Rash, and Pneumonia  

Shim, Sun Hee (Department of Pediatrics, Medical College, The Catholic University of Korea)
Kim, Ju Young (Department of Pediatrics, Medical College, The Catholic University of Korea)
Lee, Eu Kyoung (Department of Pediatrics, Medical College, The Catholic University of Korea)
Bang, Kyongwon (Department of Pediatrics, Medical College, The Catholic University of Korea)
Cho, Kyoung Soon (Department of Pediatrics, Medical College, The Catholic University of Korea)
Lee, Juyoung (Department of Pediatrics, Medical College, The Catholic University of Korea)
Suh, Jin-Soon (Department of Pediatrics, Medical College, The Catholic University of Korea)
Bin, Joong Hyun (Department of Pediatrics, Medical College, The Catholic University of Korea)
Kim, Hyun Hee (Department of Pediatrics, Medical College, The Catholic University of Korea)
Lee, Won Bae (Department of Pediatrics, Medical College, The Catholic University of Korea)
Publication Information
Pediatric Infection and Vaccine / v.21, no.1, 2014 , pp. 65-70 More about this Journal
Abstract
Although congenital syphilis can be prevented with prenatal screening, the disease remains problematic. Currently, there are no cases that describe hematuria and pneumonia related to congenital syphilis. We report a case of congenital syphilis that involved nephrotic syndrome and pneumonia alba in a 22-day-old male infant whose mother did not receive adequate prenatal care. The congenital syphilis diagnosis was confirmed with a serologic test and the patient recovered with penicillin treatment. Clinical findings may be subtle in neonates and delayed recognition occurs frequently, thus complete prenatal screening is critical for congenital syphilis prevention. Immediate serologic testing should be performed to obtain a differential diagnosis if an infant is delivered by a mother that has not received appropriate prenatal examinations.
Keywords
Congenital syphilis; Nephrotic syndrome; Pneumonia; Hematuria;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Moon KS, Kim JD, Shin MH, Oh JS. A case of nephritic syndrome in congenital syphilis. J Korean Pediatr Soc 1980;23:950-5.
2 Edell DS, Davidson JJ, Mulvihill DM, Majure M. A common presentation of an uncommon cause of neonatal respiratory distress: pneumonia alba. Pediatr Pulmonol 1993;15:376-9.   DOI   ScienceOn
3 Kim DK, Lee JB, Oh KK. Congenital syphilis: radiologic findings of early congenital syphilis. Korean J Dermatol 1985;23:39-44.
4 Han JH, Kim NS, Chung WK. Clinical observation of congenital syphilis. J Korean Pediatr Soc 1979;22:518-24.
5 Miller R, Karras DJ. Commentary. Update on emerging infections: news from the Centers for Disease Control and Prevention. Congenital syphilis--United States 2003-2008. Ann Emerg Med 2010;56:296-7.   DOI
6 Center for Disease Control and Prevention. 2011 Sexually transmitted disease surveillance. Available from URL: http://www.cdc.gov/std/syphilis2011/Syphilis-2011-All-Profiles.pdf [accessed July 7, 2013]
7 Cam H, Taytan Y, Aji DY, Bilgi Z, Aydemir E, Demirkesen C. Congenital syphilis presenting with nephrotic syndrome and leucocytoclastic vasculitis. J Eur Acad Dermatol Venereol 2004;18:484-6.   DOI
8 Roh EJ, Hong KS, Chung EH, Chang YP, Lee YS. Two cases of pneumonia alba in congenital syphilis. Pediatr All Resp Dis 2009;19:300-6.
9 Vural M, Ilikkan B, Polat E, Demir T, Perk Y. A premature newborn with vesiculobullous skin lesions. Eur J Pediatr 2003;162:197-9.
10 Niemsiri S. Congenital syphilitic nephrosis. Southeast Asian J Trop Med Public Health 1993;24:595-600.
11 Lago EG, Vaccari A, Fiori RM. Clinical features and follow-up of congenital syphilis. Sex Transm Dis 2013;40:85-94.   DOI
12 O'Regan S, Fong JS, de Chadarevian JP, Rishikof JR, Drummond KN. Treponemal antigens in congenital and acquired syphilitic nephritis: demonstration by immunofluorescence studies. Ann Intern Med 1976;85:325-7.   DOI
13 Suskind R, Winkelstein JA, Spear GA. Nephrotic syndrome in congenital syphilis. Arch Dis Child 1973;48:237-9.   DOI
14 Park HS, Moon SJ, Lee SY, Lee KS. The clinical observation of congenital syphilis. J Korean Pediatr Soc 1979;22:702-8.