Browse > Article
http://dx.doi.org/10.14776/kjpid.2014.21.1.1

Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution  

Choi, Jae Won (Department of Pediatrics, Yonsei University, Wonju College of Medicine)
Cho, Hyun Jun (Department of Pediatrics, Yonsei University, Wonju College of Medicine)
Kim, Hwang Min (Department of Pediatrics, Yonsei University, Wonju College of Medicine)
Hahn, Seok (Department of Radiology, Yonsei University, Wonju College of Medicine)
Publication Information
Pediatric Infection and Vaccine / v.21, no.1, 2014 , pp. 1-8 More about this Journal
Abstract
Purpose: The aim for this study was to investigate clinical manifestation of seasonal influenza A and B during the 2012 winter season in Wonju, South Korea. Their clinical and laboratorial characteristics and effect of oseltamivir were compared and analyzed. Methods: Children under the age of 18 years who visited the Wonju Severance Christian Hospital with fever or acute respiratory symptoms and who were diagnosed with influenza A or B by rapid antigen test from nasopharyngeal swab were selected for the study. The medical records of patients were retrospectively reviewed. Results: Influenza A was detected in 374 patients (83.7%), and influenza B in 72 (16.6%). The incidence of influenza A was highest in February (n=186), while that of influenza B was highest in March (n=36). The most common symptoms were fever (n=434, 97.1%) and cough (n=362, 81.0%). No significant differences were observed between influenza A and B in symptoms and laboratory data. Patients who had used oseltamivir within 2 days showed statistically lower admission rate, shorter admission duration, and lower incidence of pneumonia. Conclusion: This study found no statistical difference between influenza A and B, in symptoms, progression, and laboratory test, but those who were treated with oseltamivir given within 2 days of the onset of fever experienced more positive outcomes.
Keywords
Influenza; Seasonal Influenza A; Seasonal Influenza B;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Neuzil KM, Wright PF, Mitchel EF Jr, Griffin MR. The burden of influenza illness in children with asthma and other chronic medical conditions. J Pediatr 2000;137:856-64.   DOI   ScienceOn
2 van den Wijngaard CC, van Asten L, Meijer A, van Pelt W, Nagelkerke NJ, Donker GA, et al. Detection of excess influenza severity: associating respiratory hospitalization and mortality data with reports of influenza-like illness by primary care physicians. Am J Public Health 2010; 100:2248-54.   DOI   ScienceOn
3 Morris SK, Parkin P, Science M, Subbarao P, Yau Y, O' Riordan S, et al. A retrospective cross-sectional study of risk factors and clinical spectrum of children admitted to hospital with pandemic H1N1 influenza as compared to influenza A. BMJ Open 2012;2:e000310.   DOI
4 Dharan NJ, Gubareva LV, Meyer JJ, Okomo-Adhiambo M, McClinton RC, Marshall SA, et al. Infections with oseltamivir-resistant influenza A(H1N1) virus in the united states. JAMA 2009;301:1034-41.   DOI   ScienceOn
5 Wang K, Shun-Shin M, Gill P, Perera R, Harnden A. Neuraminidase inhibitors for preventing and treating influenza in children (published trials only). Cochrane Database Syst Rev 2012;4:CD002744.
6 de Jong MD, Tran TT, Truong HK, Vo MH, Smith GJ, Nguyen VC, et al. Oseltamivir resistance during treatment of influenza A (H5N1) infection. N Engl J Med 2005; 353:2667-72.   DOI   ScienceOn
7 Seo ES, Park GH, Kim SM, Kim SW, Jung WS, Cho KS, et al. Oseltamivir efficacy, side effects, and safety in children with influenza. Korean J Pediatr 2010;53:56-66.   DOI
8 Simonsen L, Clarke MJ, Williamson GD, Stroup DF, Arden NH, Schonberger LB. The impact of influenza epidemics on mortality: introducing a severity index. Am J Public Health 1997;87:1944-50.   DOI
9 Thompson WW, Moore MR, Weintraub E, Cheng PY, Jin X, Bridges CB, et al. Estimating influenza-associated deaths in the United States. Am J Public Health 2009;99 Suppl 2:S225-30.   DOI   ScienceOn
10 Wie SH, So BH, Song JY, Cheong HJ, Seo YB, Choi SH, et al. A comparison of the clinical and epidemiological characteristics of adult patients with laboratory-confirmed influenza A or B during the 2011-2012 influenza season in Korea: a multi-center study. PLoS ONE 2013;8:e62685.   DOI
11 Ginocchio CC, Zhang F, Manji R, Arora S, Bornfreund M, Falk L, et al. Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak. J Clin Virol 2009;45:191-5.   DOI   ScienceOn
12 Blyth CC, Iredell JR, Dwyer DE. Rapid-test sensitivity for novel swine-origin influenza A(H1N1) virus in humans. N Engl J Med 2009;361:2493.   DOI   ScienceOn
13 Kim WJ. Epidemiology, clinical manifestations, and management of pandemic novel Influenza A (H1N1). The Korean J Med 2009;77:157-64.
14 Kim SH, Park CH, Huh K, Shim GH, Kim HB, You SJ, et al. Comparison of clinical manifestation and laboratory findings between H1N1 and influenza B infection. Pediatr Allergy Respir Dis 2012;22:64-70.   DOI
15 Yang SI, Rho JH, Sun YH, Cho KH, Shim SY, Eun BW, et al. The comparison of clinical characteristics and courses of pediatric patients hospitalized with pandemic influenza A (H1N1) and seasonal influenza from 2009 to 2011. Pediatr Allergy Respir Dis (Korea) 2012;22:292-301.   DOI
16 Kawai N, Ikematsu H, Iwaki N, Kawashima T, Maeda T, Mitsuoka S, et al. Longer virus shedding in influenza B than in influenza A among outpatients treated with oseltamivir. J Infect 2007;55:267-72.   DOI
17 Irving SA, Patel DC, Kieke BA, Donahue JG, Vandermause MF, Shay DK, et al. Comparison of clinical features and outcomes of medically attended influenza A and influenza B In a defined population over four seasons: 2004-2005 through 2007-2008. Influenza Other Respir Viruses 2012;6:37-43.   DOI   ScienceOn
18 Sato M, Saito R, Sato I, Tanabe N, Shobugawa Y, Sasaki A, et al. Effectiveness of oseltamivir treatment among children with influenza A or B virus infections during four successive winters in Niigata City, Japan. Tohoku J Exp Med 2008;214:113-20.   DOI   ScienceOn
19 Korea Centers for Disease Control and Prevention. Korean influenza surveillance report, 2011-2012. Public Health Weekly Report 2012;5:873-81. Available at http://www.cdc.go.kr/CDC/info/CdcKrInfo0301.jsp?menuIds=HO ME001-MNU0004-MNU0036-MNU0037 [accessed on 12 Sep 2013].
20 Wright P. Influenza viruses. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: WB Saunders, 2011:1121-5.
21 Samson M, Pizzorno A, Abed Y, Boivin G. Influenza virus resistance to neuraminidase inhibitors. Antiviral Res 2013;98:174-85.   DOI   ScienceOn