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Clinical and Laboratory Finding of the 2009 Pandemic influenza A (H1N1) in Children  

Sohn, Yu Rak (Department of Pediatrics, Fatima Hospital)
Park, Su Hyun (Department of Pediatrics, Fatima Hospital)
Kim, Won Duck (Department of Pediatrics, Fatima Hospital)
Publication Information
Pediatric Infection and Vaccine / v.18, no.2, 2011 , pp. 173-181 More about this Journal
Abstract
Purpose : 2009 Pandemic influenza A (H1N1) virus was identified in March 2009 and subsequently caused worldwide outbreaks. We described the clinical and epidemiological characteristics of H1N1 influenza infection. Methods : We used retrospective medical chart reviews to collect data on the visiting patients from a single institute. H1N1 infection was confirmed in specimens with the use of a RT-PCR (real time reverse transcriptase polymerase chain reaction assay). Result : 6,836 patients had H1N1 RT-PCR test, and 2,781 were confirmed with H1N1 virus infection. 158 patients (5.7%) had hospital treatment and inpatients were significantly younger (5.4${\pm}$3.3 years) than outpatients (7.5${\pm}$3.9 years) among H1N1 virus confirmed patients. Oxygen, steroid, immunoglobulin, ventilator treatment was provided in a substantial proportion among pneumonia patients accompanying wheezy respiration. In addition more intensive care was needed in patients accompanying segmental, lobar, interstitial, mixed pneumonia and lung effusion (27.2%) than patients with bronchopneumonia (7.3%) among H1N1 virus infection confirmed patients. Seventy-one infants had oseltamivir treatment out of 83 infants under 1 year, and no significant side effects and complications were identified. Conclusion : In 2009 pandemic influenza A (H1N1), hospital treatment was needed in younger patients. Early intensive care was needed in pneumonia patients accompanying wheezy respiration, and patients accompanying segmental, lobar, interstitial, mixed pneumonia and lung effusion.
Keywords
H1N1; Pneumonia; Asthma; Oseltamivir;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Cunha BA, Swine Influenza (H1N1) Pneumonia: Clinical Considerations. Infect Dis Cli Am 2009;24:203-28.
2 Dawood FS, Kamimoto L, D'Mello TA, Reingold A, Gershman K, Meek J. Children with asthma hospitalized with seasonal or pandemic influenza, 2003-2009. Pediatrics 2011;12:e27-32. Epub 2011 Jun 6.
3 Smith JR, Ariano RE, Toovey S. The use of antiviral agents for the management severe influenza. Cric Care Med 2010;38:e43-51.   DOI
4 Okamoto S, Kamiya I, Kishida K, Shimakawa T, Fukui T, Morimoto T. Experience with oseltamivir for infants younger than 1 year old in Japan. Pediatr Infect Dis J 2005;24:575-6.   DOI   ScienceOn
5 Tamura D, Miura T, Kikuchi Y. Oseltamivir phosphate in infants under 1 year of age with influenza infection. Pediatr Int 2005;47:484.   DOI   ScienceOn
6 CDC Seasonal Flu Website. Recommendations for Use of Antiviral Medications for the Management of Influenza in Children and Adolescent for the 2009-2010 Season - Pediatric Supplement for Health Care Providers. Available at: http://www.cdc.gov/h1n1flu/recommendations_pediatric_supplement.htm
7 Centers for Disease Control and Prevention (CDC). Outbreak of swine origin influenza A (H1N1) virus infection-Mexico, March-April 2009. MMWR Morb Mortal Wkly Rep 2009;58:467-70.
8 Influenza A (H1N1)- update 44. Geneva: WHO, 2009. Available at: http://www.who.int/csr/don/2009_06_05/en/index.html. Accessed 6 June 2009.
9 CDC. CDC Estimates of 2009 H1N1 Influenza Cases, Hospitalizations and Deaths in the United States, April - December 12, 2009. Available at: http://www.cdc.gov/h1n1flu/estimates/April_December_12.htm
10 Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605-15.   DOI   ScienceOn
11 Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Griffin J, Hollingsworth TD, et al. Pandemic potential of a strain of influenza A (H1N1): early findings. Science 2009;324:1557-61.   DOI   ScienceOn
12 Turbelin C, Pelat C, Boelle PY, Levy-Bruhl D, Carrat F, Blanchon T, et al. Early estimates of 2009 pandemic influenza A(H1N1) virus activity in general practice in France: incidence of influenza-like illness and age distribution of reported cases. Euro Surveill 2009;14:19341.
13 Garske T, Legrand J, Donnelly CA, Ward H, Cauchemez S, Fraser C, et al. Assessing the severity of the novel influenza A/H1N1 pandemic. BMJ 2009;339:b2840.   DOI   ScienceOn
14 Peiris J, Poon L, Guan Y. Emergence of a novel swineorigin influenza A virus (S-OIV) H1N1 virus in humans. Journal of Clinical Virology 2009;45:169-73.   DOI   ScienceOn
15 Korea Center for Disease Control and Prevention (KCDC). Epidemiology of early detected Novel Influenza A (H1N1) in Korea, 2009. Public Health Wkly Rep 2009;2:689-91.
16 Garten RJ, Davis CT, Russell CA, Shu B, Lindstorm S, Balish A, et al. Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Science 2009;325:197-201.   DOI   ScienceOn
17 Loftus BG, Price JF. Clinical and immunological characteristics of pre-school asthma. Clin Allergy 1986;16:251-7   DOI
18 Neumann G, Noda T, Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009;459:931-9.   DOI   ScienceOn
19 Seong HW, Woo JK. Diagnosis and management of novel influenza A(H1N1). Korean J Fam Med 2009;30:843-7.   DOI
20 Public Health Agency of Canada. Flu watch: July 5, 2009 to July 11, 2009 (week 27). http://www.phac-aspc.gc.ca/fluwatch/08-09/w27_09/index-eng.php. Accessed July 20, 2009.
21 Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis 1998;178:53-60.   DOI   ScienceOn
22 Hui DS, Lee N, Chan PK. Clinical management of pandemic 2009 influenza A (H1N1) infection. Chest 2010;137:916-25.   DOI   ScienceOn
23 Kim SH. Treatment of severe pandemic influenza A/H1N1 Infection. Infect Chemother 2009;5:265-71.
24 Faix DJ, Sherman SS, Waterman SH. Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;361:728-9.   DOI   ScienceOn
25 Lee HJ, Min SJ, Choi JW, Kang EK. Clinical characteristics of hospitalized pediatric patients with 2009 novel influenza A infection. Pediatr Allergy Dis (Korea) 2010;20:130-7.
26 Reddy D. Responding to pandemic (H1N1) 2009 influenza: the role of oseltamivir. J Antimicrob Chemother 2010;65 Suppl 2:ii35-40.
27 CDC. Surveillance for pediatric deaths associated with 2009 pandemic influenza A (H1N1) virus infection - United States, April-August 2009. MMWR Morb Mortal Wkly Rep 2009;58:941-7.
28 Barlow GD; BSAC Council. Swine flu and antibiotics. J Antimicrob Chemother 2009;64:889-94.   DOI   ScienceOn
29 Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quinoses-Falcon F, Bautista E et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Eng J Med 2009;361:680-9.   DOI   ScienceOn
30 Mollura DJ, Aspis DS, Conetta R, Feign DS, Bray M, Taubenberger JK, et al. Imaging findings in a fatal case of pandemic swine-origin influenza A (H1N1). AJR Am J Roentgenol 2009;193:1500-3.   DOI   ScienceOn
31 Agarwal PP, Cinti S, Kazerooni EA. Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection. AJR Am J Roentgenol 2009;193:1488-93.   DOI   ScienceOn
32 Jain S, Kamimoto L, Bramley AM, Schmitz AM, Louie J, Sugerman DE, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Eng J Med 2009;361:1935-44.   DOI   ScienceOn
33 Quispe-Laime AM, Bracco JD, Barberio PA, Campagne CG, Rolfo VE, Umberger R, et al. H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment. Intensive Care Med 2010;36:33-41.   DOI   ScienceOn