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The Effects of PCB on the Embryonic Development of a Korean Frog, Rana dybowskii  

Ko Sun-Kun (호남대학교 생명과학과)
Joung Soung-Yung (호남대학교 대학원 생물학과)
Publication Information
Korean Journal of Environment and Ecology / v.18, no.3, 2004 , pp. 340-345 More about this Journal
Abstract
The embryotoxic effects of PCB (Aroclor 1248) on a Korean frog, Rana dybowskii was deter-mined by using the FETAX (Frog Embryo Teratogenesis Assay-Xenopus) protocol. The rates of mortality and malformed larvae were investigated by probit analysis. The results showed that PCB is highly embryolethal. From LC$_{50}$ of 1.48ppb and from EC$_{50}$ of 0.25ppb and TI of 5.7 were derived, which indicates PCB is to be considered a teratogenic compound. Specific malformations occurred in 62.0% as edema at the 0.1ppb, in 32.0% as tail deformations at the 1ppb, and in 68.0% as profound deformations at the 5ppb of PCB concentration which living embryos were exposed to. PCB suppressed the growth of head-tail length at a relatively low concentration (1.0ppb), and therefore growth inhibition as assessed by embryo length can be used as a sensitive indicator to evaluate the toxicity of pollutants in the environment. In conclusion, PCB must be considered highly embryotoxic to Rana dybowskii.
Keywords
TERATOGENESIS;
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Times Cited By KSCI : 1  (Citation Analysis)
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