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http://dx.doi.org/10.5668/JEHS.2022.48.1.36

Preservatives in Domestic and Imported Children's Clay Products  

Jung, Sun Hye (Department of Health, Environment & Safety, Eulji University)
Heo, Jin Yeong (Department of Health, Environment & Safety, Eulji University)
Oh, Ji Hee (Department of Health, Environment & Safety, Eulji University)
Park, Na-Youn (Department of Health, Environment & Safety, Eulji University)
Kho, Younglim (Department of Health, Environment & Safety, Eulji University)
Publication Information
Journal of Environmental Health Sciences / v.48, no.1, 2022 , pp. 36-43 More about this Journal
Abstract
Background: Preservatives are used to prevent product deterioration in modeling clay. Parabens, a representative preservative, have been found to be endocrine disruptors and cause skin irritation and allergic reactions. Isothiazolinone preservatives can be irritating to the skin, respiratory tract, and eyes. Thorough investigation and regulation of clay are necessary because clay is marketed to children, who are more sensitive to the toxic effect of chemicals. Objectives: In this study, the presence of 16 preservatives was analyzed in modeling clay and the results were compared with current standards. Methods: A total of 200 samples were collected from 28 children's clay products sold in South Korea (13 from Korea and 15 imported from overseas). Twelve preservatives, such as parabens, were analyzed using high-performance liquid chromatography (HPLC). Isothiazolinone preservatives (chloromethylisothiazolinone; CMIT, methylisothiazolinone; MIT, octylisothiazolinone; OIT, and benzisothiazolinone; BIT) were analyzed using ultra performance liquid chromatography-tandem mass spectrometery (UPLC-MS/MS). Results: Dehydroacetic acid (DHA) was detected the most in the clays at 51.50% (103 cases) detection; 38 cases (median 190.42 ㎍/g) in Korean products and 65 cases (median 169.62 ㎍/g) in Chinese products. CMIT, which is prohibited in Korea, was detected in 14 (median 16.28 ㎍/g) Chinese products. OIT, which has a chemical structure similar to CMIT was found in 28 (median 68.38 ㎍/g) samples in Korean products. Conclusions: The use of CMIT and MIT in children's products is prohibited in Korea and the European Union (EU). The detection of CMIT in Chinese clay products suggests that management is necessary for imported products. It is necessary to review the safety and regulatory status for OIT because OIT was used as a substitute for CMIT and MIT in Korean products.
Keywords
Clay; preservatives; CMIT; OIT; UPLC-MS/MS;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Environment Digital Library Search. 2018 Environmental Hazardous Factor Investigation Project for Children's Products. Available: https://library.me.go.kr/#/search/detail/5685595 [accessed 20 December 2020].
2 Korean Agency for Technology and Standards. Special Act on The Safety of Children's Products Annex 11(School Things - 17.1.31). Available: https://www.kats.go.kr/content.do?cmsid=530&searchField=title&searchValue=%ED%95%99%EC%9A%A9%ED%92%88&y=0&x=0&mode=view&page=1&cid=19279 [accessed 30 July 2021].
3 Ministry of Food and Drug Safety. Analytical Method for Cosmetic. Available: https://www.mfds.go.kr/brd/m_641/view.do?seq=26176&srchFr=&srchTo=&srchWord=%EC%8B%9C%ED%97%98%EB%B2%95&srchTp=0&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&Data_stts_gubun=C9999&page=1 [accessed 4 May 2021].
4 Wang J, Ren JF, Zhang DL, Zhou M, Li ZG, Zhang HM. Determination of three isothiazolinone preservatives in children's color clay modeling toys by high performance liquid chromatographytandem mass spectrometry. J Instrum Anal. 2019; 38(11): 1384-1388.
5 Korean Agency for Technology and Standards. Special Act on The Safety of Children's Products Annex 6 (Toys - 21.7.1). Available: https://www.kats.go.kr/content.do?cmsid=530&mode=view&page=&cid=22221 [accessed 30 July 2021].
6 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, et al. Safety assessment of benzyl alcohol, benzoic acid and its salts, and benzyl benzoate. Int J Toxicol. 2017; 36(3 Suppl): 5S-30S.
7 Access to European Union Law. Commission Directive (EU) 2015/2117 Appendix C of Annex II (MIT, CMIT, CMIT/MIT(3:1)). https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32015L2117&qid=1640839498744 [accessed 31 October 2021].
8 National Chemicals Information System. Detail Information (MIT). Available: https://ncis.nier.go.kr/mttr/mttrList.do [accessed 17 November 2021].
9 Ministry of Trade, Industry and Energy. Slime 100 Product Recall Orders. Available: http://www.motie.go.kr/motie/ne/presse/press2/bbs/bbsView.do?bbs_cd_n=81&bbs_seq_n=162307 [accessed 19 March 2021].
10 Lee HM, Jung KH. Chemical risk factors for children's health and research strategy. J Food Hyg Saf. 2008; 23(3): 276-283.
11 Ministry of Environment of Denmark. Survey and Health Assessment of Preservatives in Toys. Available: https://mst.dk/service/publikationer/publikationsarkiv/2014/feb/survey-and-healthassessment-of-preservatives-in-toys/ [accessed 16 June 2021].
12 Ryu YJ. Simultaneous analysis and monitoring of thirteen preservatives in cosmetics by liquid chromatography [dissertation]. [Ceongju]: Chungbuk National University; 2013.
13 National Chemicals Information System. Detail Information (CMIT). Available: https://ncis.nier.go.kr/mttr/mttrList.do [accessed 17 November 2021].
14 Environment Digital Library Search. 2019 Environmental Hazardous Factor Investigation Project for Children's Products. Available: https://library.me.go.kr/#/search/detail/5717868 [accessed 20 December 2020].
15 Korea Legislation Research Institute. Cosmetics Act- Article 8 (Safety Standards for Cosmetics). Available: https://elaw.klri.re.kr/kor_service/lawView.do?hseq=52153&lang=ENG&joseq=JO0008000&searchTxt=%25ED%2599%2594%25EC%259E%25A5%25ED%2592%2588%2520%25EC%2595%2588%25EC%25A0%2584%25EA%25B8%25B0%25EC%25A4%2580 [accessed 12 November 2021].
16 National Institute of Food and Drug Safety Evaluation. Integrated Risk Assessment of Parabens. Available: http://www.nifds.go.kr/brd/m_18/view.do?seq=12507 [accessed 1 October 2021].
17 National Chemicals Information System. Detail Information (OIT). Available: https://ncis.nier.go.kr/mttr/mttrList.do [accessed 17 November 2021].
18 National Institute of Food and Drug Safety Evaluation. Tox - Info Benzoic Acid (BA). Available: https://www.nifds.go.kr/toxinfo/tcd/info/tcdDetailPop.do?toxicCode=T2000000205 [accessed 4 February 2022].
19 Korea Disease Control and Prevention Agency. 2017 Child Growth Standards. Available: https://knhanes.kdca.go.kr/knhanes/sub08/sub08_02.do [accessed 4 February 2022].
20 Chemical News. [Harmful Substances in Children's Health and Daily Life] Parabens. Available: http://www.chemicalnews.co.kr/news/articleView.html?idxno=1165 [accessed 16 December 2020].
21 Korea Consumer Agency. Children's Clay Safety Survey. Available: https://www.kca.go.kr/smartconsumer/sub.do?menukey=7301&mode=view&no=1002535699 [accessed 28 February 2021].
22 Ahn HS, Nah WH, Lee JE, Oh YS, Gye MC. Toxicity and endocrine disrupting effect of parabens. Korean J Environ Biol. 2009; 27(4): 323-333.
23 Guak SY, Lim MY, Shin HR, Park JY, Lee KY. Determination of skin adhesion rate of children's modeling clay for exposure assessment. J Environ Health Sci. 2018; 44(3): 238-243.
24 Cohen Hubal EA, Sheldon LS, Burke JM, McCurdy TR, Berry MR, Rigas ML, et al. Children's exposure assessment: a review of factors influencing children's exposure, and the data available to characterize and assess that exposure. Environ Health Perspect. 2000; 108(6): 475-486.   DOI
25 Korea Legislation Research Institute. Special Act on The Safety of Children's Products - Article 2 (Definitions). Available: https://elaw.klri.re.kr/kor_service/lawView.do?hseq=42349&lang=ENG [accessed 3 February 2022].
26 Heo DA, Huh EH, Park JY, Moon KW, Lee KY. An investigation of ingredients and hazardous substances in some consumer products - focusing on cleaners and disinfectants. J Environ Health Sci. 2015; 41(5): 314-326.   DOI
27 Korea Institute of Toxicology. [Research Talk] Humidifier Disinfectant Ingredients CMIT/MIT Harmfulness, Scientific Proof. Available: https://www.kitox.re.kr/keytalks/research_talk/view/page/7/id/21067#u [accessed 24 October 2021].
28 Access to European Union Law. Commission Directive (EU) 2015/2116 Appendix C of Annex II (BIT). Available: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32015L2116&qid=1640839031445 [accessed 31 October 2021]
29 Jung SJ, Hwang YS, Choi CM, Park AS, Kim SU, Kim HJ, et al. Examination and quantification of preservatives in cosmetics for children. J Soc Cosmet Sci Korea. 2015; 41(3): 219-227.   DOI