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http://dx.doi.org/10.5668/JEHS.2011.37.2.081

Pesticide Exposure and Health  

Lee, Won-Jin (Department of Preventive Medicine, College of Medicine, Graduate School of Public Health, Korea University)
Publication Information
Journal of Environmental Health Sciences / v.37, no.2, 2011 , pp. 81-93 More about this Journal
Abstract
Although pesticides have increased crop production and controlled disease, they have produced a number of adverse health effects. Pesticides have potential human toxicity and a variety of groups, such as farmers or industrial workers, as well as the general population, are exposed to pesticides. The purpose of this article, therefore, is to provide an overview of pesticide exposure and health through a literature review, focusing on exposure assessment, acute poisoning, chronic health effects, and future research needs. The exposure types and levels of pesticides vary by study subjects and need to be assessed by integrating several methods focused on the epidemiological purpose. Acute pesticide poisoning is a major public health problem in the world. Paraquat is the main causative pesticide for acute poisoning in Korea and should be banned in order to save several thousands of lives every year. Occupational pesticide exposure also causes numerous chronic diseases among farmers and industrial workers, including cancers, respiratory diseases, depression, retinal degeneration, diabetes, and abnormal menstrual cycle. However, controversy exists regarding the long-term effects of low-dose environmental pesticide exposure. The area of pesticide study is relatively new with broad study populations and it has received little academic and policy attention, particularly in Korea. More detailed studies investigating the risk of pesticide-related health effects and intervention efforts to reduce the problems are needed in Korea.
Keywords
Agricultural chemicals; Agricultural workers; Diseases; Environmental exposure; Occupational exposure;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Swirsky Gold L, Stern BR, Slone TH, Brown JP, Manley NB, Ames BN. Pesticide residues in food: investigation of disparities in cancer risk estimates. Cancer Lett. 1997; 117(2): 195-207.   DOI   ScienceOn
2 Chun OK, Kang HG. Estimation of risks of pesticide exposure, by food intake, to Koreans. Food Chem Toxicol. 2003; 41(8): 1063-1076.   DOI   ScienceOn
3 Ames BN, Gold LS. Environmental pollution, pesticides, and the prevention of cancer: misconceptions. FASEB J. 1997; 11(13): 1041-1052.   DOI
4 Tomatis L, Melnick RL, Haseman J, Barrett JC, Huff J. Alleged misconceptions' distort perceptions of environmental cancer risks. FASEB J. 2001; 15(1): 195-203.   DOI   ScienceOn
5 International Agency for Research on Cancer. AGRICOH: A Consortium of Agricultural Cohort Studies. Available: http://agricoh.iarc.fr. [accessed 15 April 2011]
6 Lee WJ, Purdue M, Stewart P, Schenk M, De Roos AJ, Cerhan JR, et al. Occupational exposure to pesticides, asthma history, and the risk of non-Hodgkin lymphoma. Int J Cancer. 2006; 118(12): 3174-3176.   DOI   ScienceOn
7 Rosas LG, Eskenazi B. Pesticides and child neurodevelopment. Curr Opin Pediatr. 2008; 20(2): 191-197.   DOI   ScienceOn
8 Lee WJ, Cha ES, Park ES, Kong KA, Yi JH, Son M. Deaths from pesticide poisoning in South Korea: trends over 10 years. Int Arch Occup Environ Health. 2009; 82(3): 365-371.   DOI   ScienceOn
9 Lee WJ, Cha ES. Overview of pesticide poisoning in South Korea. J Rural Med. 2009; 4(2): 53-58.   DOI
10 Rural Development Administration. Researches on the actual state of pesticide poisoning in Korea and guidelines for diagnosis and treatment of paraquat and organophosphate poisoning. Suwon, Republic of Korea: Rural Development Administration; 2008.
11 Lock EA, Wilks MF. Paraquat. In: Krieger R. editor. Hayes' Handbook of Pesticide Toxicology, 3rd ed. San Diego: Academic Press; 2010. p.1771-827.
12 Agricultural Health Study. Available: http://www.aghealth.org/ [accessed 15 April 2011].
13 International Agency for Research on Cancer. Occupational exposures in insecticide application, and some pesticides. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon: IARC Monogr Eval Carcinog Risks Hum; 1991. p.5-586.
14 Weichenthal S, Moase C, Chan P. A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort. Environ Health Perspect. 2010; 118(8): 1117-1125.   DOI   ScienceOn
15 Dawson AH, Eddleston M, Senarathna L, Mohamed F, Gawarammana I, Bowe SJ, et al. Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Med. 2010; 7(10): e1000357.   DOI   ScienceOn
16 Lee WJ, Blair A, Hoppin JA, Lubin JH, Rusiecki JA, Sandler DP, et al. Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. J Natl Cancer Inst. 2004; 96(23): 1781-1789.   DOI   ScienceOn
17 Damgaard IN, Skakkebaek NE, Toppari J, Virtanen HE, Shen H, Schramm KW, et al. Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect. 2006; 114(7): 1133-1138.   DOI   ScienceOn
18 Cox C, Surgan M. Unidentified inert ingredients in pesticides: implications for human and environmental health. Environ Health Perspect. 2006; 114(12): 1803-1806.
19 Sheiner EK, Sheiner E, Hammel RD, Potashnik G, Carel R. Effect of occupational exposures on male fertility: literature review. Ind Health. 2003; 41(2): 55-62.   DOI
20 Farr SL, Cai J, Savitz DA, Sandler DP, Hoppin JA, Cooper GS. Pesticide exposure and timing of menopause. Am J Epidemiol. 2006; 163(8): 731-742.   DOI   ScienceOn
21 Steerenberg P, van Amelsvoort L, Colosio C, Corsini E, Fustinoni S, Vergieva T, et al. Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. Hum Exp Toxicol. 2008; 27(9): 701-707.   DOI
22 Kamel F, Boyes WK, Gladen BC, Rowland AS, Alavanja MC, Blair A, et al. Retinal degeneration in licensed pesticide applicators. Am J Ind Med. 2000; 37(6): 618-628.   DOI   ScienceOn
23 Dosemeci M, Alavanja MC, Rowland AS, Mage D, Zahm SH, Rothman N, et al. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg. 2002; 46(2): 245-260.   DOI   ScienceOn
24 U. S. Environmental Protection Agency. Pesticides industry sales and usage. 2006 and 2007 market estimates. Available: http://www.epa.gov/opp00001/pestsales/07pestsales/market_estimates2007.pdf [accessed 15 April 2011].
25 Korea crop protection association. Pesticide handbook 2009. Available: http://www.koreacpa.org/ [accessed 15 April 2011].
26 Alavanja MC, Hoppin JA, Kamel F. Health effects of chronic pesticide exposure: cancer and neurotoxicity. Annu Rev Public Health. 2004; 25: 155-197.   DOI   ScienceOn
27 Thomas KW, Dosemeci M, Coble JB, Hoppin JA, Sheldon LS, Chapa G, et al. Assessment of a pesticide exposure intensity algorithm in the Agricultural Health Study. J Expo Sci Environ Epidemiol. 2010; 20(6): 559-569.   DOI   ScienceOn
28 Maroni M, Colosio C, Ferioli A, Fait A. Biological monitoring of pesticide exposure: a review. Toxicology. 2000; 143(1): 1-118.   DOI   ScienceOn
29 Lee YH, Cha ES, Moon EK, Kong KA, Koh SB, Lee YK, et al. Reliability of self-reported information by farmers on pesticide use. J Prev Med Public Health. 2010; 43(6): 535-542.   과학기술학회마을   DOI   ScienceOn
30 Montgomery MP, Kamel F, Saldana TM, Alavanja MC, Sandler DP. Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003. Am J Epidemiol. 2008; 167(10): 1235-1246.   DOI   ScienceOn
31 Mackness B, Durrington P, Povey A, Thomson S, Dippnall M, Mackness M, et al. Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics. 2003; 13(2): 81-88.   DOI
32 Eskenazi B, Huen K, Marks A, Harley KG, Bradman A, Barr DB, et al. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environ Health Perspect. 2010; 118(12): 1775-1781.   DOI   ScienceOn
33 Centers for Disease Control and Prevention. Third National Report on Human Exposure to Environmental Chemicals. Available: http://www.cdc.gov/nchs/nhanes.htm [accessed 15 April 2011].
34 Lee WJ, Alavanja MCR, Hoppin JA, Kamel F, Rusiecki JA, Blair A, et al. Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. Environ Health Perspect. 2007; 115(4): 528-534.   DOI   ScienceOn
35 Brown TP, Rumsby PC, Capleton AC, Rushton L, Levy LS. Pesticides and Parkinson's disease--is there a link? Environ Health Perspect. 2006; 114(2): 156-164.   DOI   ScienceOn
36 Park J, Yoo CI, Sim CS, Kim HK, Kim JW, Jeon BS, et al. Occupations and Parkinson's disease: a multi-center case-control study in South Korea. Neurotoxicology. 2005; 26(1): 99-105.   DOI   ScienceOn
37 Park SK, Kong KA, Cha ES, Lee YJ, Lee GT, Lee WJ. Occupational exposure to pesticides and nerve conduction studies among farmers. Arch Environ Occup Health, in print.
38 Hoppin JA, Umbach DM, London SJ, Lynch CF, Alavanja MC, Sandler DP. Pesticides and adult respiratory outcomes in the Agricultural Health Study. Ann N Y Acad Sci. 2006; 1076: 343-354.   DOI   ScienceOn
39 Taylor JT, Davis E, Dabisch P, Horsmon M, Matson K, Crouse C, et al. Acute toxic effects of inhaled dichlorvos vapor on respiratory mechanics and blood cholinesterase activity in guinea pigs. Inhal Toxicol. 2008; 20(5): 465-472.   DOI   ScienceOn
40 Peiris-John RJ, Ruberu DK, Wickremasinghe AR, van-der-Hoek W. Low-level exposure to organophosphate pesticides leads to restrictive lung dysfunction. Respir Med. 2005; 99(10): 1319-1324.   DOI   ScienceOn
41 Chakraborty S, Mukherjee S, Roychoudhury S, Siddique S, Lahiri T, Ray MR. Chronic exposures to cholinesterase-inhibiting pesticides adversely affect respiratory health of agricultural workers in India. J Occup Health. 2009; 51(6): 488-497.   DOI   ScienceOn
42 Chatzi L, Alegakis A, Tzanakis N, Siafakas N, Kogevinas M, Lionis C. Association of allergic rhinitis with pesticide use among grape farmers in Crete, Greece. Occup Environ Med. 2007; 64(6): 417-421.
43 Jones DR, Sutton AJ, Abrams KR, Fenty J, Warren F, Rushton L. Systematic review and meta-analysis of mortality in crop protection product manufacturing workers. Occup Environ Med. 2009; 66(1): 7-15.   DOI   ScienceOn
44 Lee WJ, Alavanja MCR. Pesticides and Cancer. In: Golson JG, Colditz GA. Encyclopedia of Cancer and Society. Thousand Oaks: SAGE publications; 2007. p.670-673.
45 Cohn BA, Wolff MS, Cirillo PM, Sholtz RI. DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect. 2007; 115(10): 1406-1414.
46 Infante-Rivard C, Weichenthal S. Pesticides and childhood cancer: an update of Zahm and Ward's 1998 review. J Toxicol Environ Health B Crit Rev. 2007; 10(1-2): 81-99.   DOI   ScienceOn
47 Sull JW, Yi SW, Sohn TY, Jee SH, Nam CM, Ohrr HC. Pesticides and cancer incidence: The Kangwha Cohort Study. Korean J Prev Med. 2002; 35(1): 24-32.   과학기술학회마을
48 Beseler CL, Stallones L. A cohort study of pesticide poisoning and depression in Colorado farm residents. Ann Epidemiol. 2008; 18(10): 768-774.   DOI   ScienceOn
49 Lee WJ, Son M, Chun BC, Park ES, Lee HK, Coble J, et al. Cancer mortality and farming in South Korea: an ecologic study. Cancer Cause Control. 2008; 19(5): 505-513.   DOI
50 Lee WJ, Cha ES, Moon EK. Disease prevalence and mortality among agricultural workers in Korea. J Korean Med Sci. 2010; 25: S112-S118.   DOI   ScienceOn
51 Beseler C, Stallones L, Hoppin JA, Alavanja MC, Blair A, Keefe T, et al. Depression and pesticide exposures in female spouses of licensed pesticide applicators in the Agricultural Health Study cohort. J Occup Environ Med. 2006; 48(10): 1005-1013.   DOI   ScienceOn
52 London L, Flisher AJ, Wesseling C, Mergler D, Kromhout H. Suicide and exposure to organophosphate insecticides: cause or effect? Am J Ind Med. 2005; 47(4): 308-321.   DOI   ScienceOn
53 Kim HJ, Cha ES, Moon EK, Ko Y, Kim J, Jeoung M, et al. A pilot study for pesticide poisoning symptoms and information on pesticide use among farmers. J Environ Health Sci. 2011; 37(1): 22-28.
54 Blair A, Freeman LB. Epidemiologic studies in agricultural populations: observations and future directions. J Agromedicine. 2009; 14(2): 125-131.   DOI   ScienceOn
55 Jeyaratnam J. Acute pesticide poisoning: a major global health problem. World Health Stat Q. 1990; 43(3): 139-144.
56 Gunnell D, Eddleston M, Phillips MR, Konradsen F. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health. 2007; 7: 357.   DOI   ScienceOn