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The Effect of Cichorium intybus Extract on Hepatotoxicity in Rats  

Park Ji-Young (Department of Oriental Medicine Resources, Hyechon College)
Kim Eun-Kyung (Department of Nursing, Hyechon College)
Publication Information
Journal of Environmental Health Sciences / v.32, no.3, 2006 , pp. 235-239 More about this Journal
Abstract
Cichorium intybus (Compositae) has been used for fevers, dyspepsia, headache and jaundice, as a demulcent. Also, it has relaxation effects and relief effects against coffee and teas, and is widely used as food. We investigated anti-lipid peroxidative effects and liver protective activity on $CCl_4$ induced lipid peroxidation and hepatotoxicity in rats. MeOH Ex. enhanced the inhibition of anti-lipid peroxidative effects in liver lipid. In chemical parameters obtained from serum analysis, MeOH Ex. revealed significant decrease on hepatotoxicity. The results were as follows; 1. The inhibitory effects of lipid peroxidation were shown in accordance with the increase of samples' concentration level. 2. In chemical parameters obtained from serum analysis, the activities of GOT, GPT, AlP were restored to near the normal level. The contents of cholesterol and BUN showed inhibitory effects with valence. 3. The weights of liver and spleen were not able to restore to the normal level. But on a general level, they were reduced more than the control group.
Keywords
Cichorium intybus; anti-lipid peroxidation; hepatotoxicity;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Chopra, R.N. : Indigenous Drugs of India, Art, 318-323, 1933
2 Mitton, F. and Mitton, V. : Mitton's Practical Modern Herbal. London W. Foulsham & Co. Ltd., 150-151, 1976
3 B. Chance, H. Sies and A. Boveris : Hydroperoxide metabolism mammalian organs physiol. Rev., 59, 527-536, 1979
4 Shahina, A. Ghazanfar : Handbook of Arabian medicinal Plants, 42-49, CRC Press, U.S.A., 1994
5 Lee, S.L. and Kim, J.G. : Inhibitory Effect of Doenjang (Korean Fermented Soybean Paste) and Soybean Extracts on the Growth of KB Cells. Kor. J. Env. Hlth., 31(5), 444-450, 2005   과학기술학회마을
6 Singh, R. and Bhatia, I.S. : Substrate specificity of fructosyl transferate from chicory roots. Pyotochem, 10, 2037-2039, 1971   DOI   ScienceOn
7 Broun, Stewart A. : Biosynthesis of 6, 7-dihydroxycoumarin in Cichorium intybus. Can. J. Biochem. Cell Biol., 63, 292-301, 1983   DOI
8 Baleym, L.H. : The Standard Cyclopedia of Horticulture, 1, 746-750, N.Y., Macmillan Company, 1942
9 Khali, A.T., Adb El-Fattah, and Mansour, E.S. : Guaianolides from lactuca saligna. Planta Medica, 57, 190-197, 1991   DOI   ScienceOn
10 Seo, B.G. and Kim, Y.B. : Effects of Aralia elata on Lipid peroxidation. Yakhak Hoeji, 37, 270-275, 1993
11 Ki, C.G., Yim, D.S. and Lee, S.Y. : Biological activities of the root of Cichorium intybus. Natural Product Science, 155-158, 1999
12 Basu, S., Smedman, S. and Vessby, B. : Conjugated dienoic acid induces lipid peroxidation in humans, FEBS Lett., 468, 33-36, 2000   DOI   ScienceOn
13 Yagik : A simple fluormetric assay for lipid peroxide in blood plasma. Biochem. Med., 15, 212-219, 1976   DOI   ScienceOn
14 Waczynski, R. and Swierczynski, A. : In Technology of Concentrated Foods (in Polish), NT, Warsaw, 277-280, 1970
15 Xu, J. and Hu, Q. : Effect of foliar application of selenium on the antioxidant activity of aqueous and ethanolic extracts of selenium-enriched rice. J. Agric. Food Chem., 52, 1759-1768, 2004   DOI   ScienceOn
16 Krystyna Mrugasiewicz, Piotr Gorecki, Alina Czarcinska : Sposob otrzymywania 6-hydroksy-7-0-glukozoksykumaryny kwiatostanow podroznika; Instytut Przemyslu Zie4larskiego, Poznan, 122567, 1984
17 Wren, R.C. and Wren, R.W. : Potter's New Cyclopaedia of Botanical Drugs and Preparations. New ed., Hengiscote, England, Health Science Press, 655-656, 1975
18 Muschler, R. : A Manual Flora of Egypt., 2, 1045-1048, 1912
19 Lee, C.G. and Kim, N.J. : Anti lipid peroxidation and liver protective effects of polygonum aviculare L. Kor. J. Pharmacogn, 25(1), 59-66, 1994
20 Zhou, K., Laux, J.J. and Yu, L. : Comparision of Swiss red wheat grain and fractions for their antioxidantproperties. J. Agric. Food Chem., 52, 1118-1123, 2004   DOI   ScienceOn
21 Clarke, R.J. and Macrae, R. : Coffee, 3-9, Elsevier Applied Science. London, N.Y., 1989
22 Lee, S.L. and Kim J.G. : Anti-microbial activity of soybean extract against oral microbes. Kor. J. Env. Hlth., 32(2), 192-197, 2006   과학기술학회마을
23 Han, Y.N. and Oh, H.K. : Antioxidant components of Gardenia fruit. Kor. J. Pharmacogn., 25(3), 226-232, 1994   과학기술학회마을
24 Huxley, A., M.G., M.L. : The New Royal Horticultural Society Dictionary of Gardening. 4, Macmillian Publising Company, London, 622-625, 1992
25 John D. Bauer : Clinical laboratory methods, nine edition, The C.V. Mosby Co.S.C.L. 535-538, 1982
26 Beitter, H. in Literatur Heinlich, T. : Rosten und Rostwaren, zweite volling neue Bearbeitung, 467-475, Verlag B. Heller, Munchen, 1934
27 Zinke, A. und holzer, K. : Uber die Bitterstoffe der Zichorie, I. Kurze Mitteliung, Lactucin und Lactucopikrin. Mh. Chem., 84, 212-220, 1953
28 Park, J.Y. and Kim, N.J. : The effects of chelidonii herba extract on the cell mediate and humoral immune responses in mice. Kor. J. Env. Hlth., 31(1), 66-72, 2005   과학기술학회마을