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Cyanobacterial Toxins, Drinking Water and Human Health  

Wickramasinghe Wasantha A. (National Research Centre for Environmental Toxicology(EnToX) University of Queensland)
Shaw Glen R. (National Research Centre for Environmental Toxicology(EnToX) University of Queensland)
Publication Information
Journal of Environmental Health Sciences / v.31, no.3, 2005 , pp. 192-198 More about this Journal
Abstract
The occurrence of toxic cyanobacterial blooms has been reported worldwide and poses a threat to human health through drinking water exposure. The toxins they produce are highly water soluble and can leach into the water body. To eliminate any risk of drinking water exposure, removal of these toxins is essential before the water is consumed. Conventional water treatment techniques such as chlorination, if managed well, can be effectively used to remove some of these toxins, however, saxitoxin and its derivatives pose a problem. Little toxicological data are available to evaluate the real threat of these toxins.
Keywords
cyanobacterial; toxin; drinking water; guideline;
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1 Banker, R., Carmeli, S., Hadas, O., Teltsch, B., Porat, R. and Sukenik, A. : Identification of cylindrospermopsin in Aphanizomenon ovalisporum (Cyanophyceae) isolated from Lake Kinneret, Israel. Journal of Phycology, 33(4), 613-616, 1997   DOI   ScienceOn
2 Byth, S. : Palm Island Mystery Disease. Medical J. of Australia, 2, 40-42, 1980
3 Carmichael, W.W. : The Toxins of Cyanobacteria., Scientific American, 270, 78-86, 1994   DOI   ScienceOn
4 Chorus, I. and Bartram, J. (Eds) : Toxic Cyanobacteria in Water: A Guide to their Public Health Consequences, Monitoring and Management. E & FN Spon, London, 1999
5 Humpage, A.R. and Falconer, I.R. : Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male Swiss albino mice: dertermination of no observed adverse effect level for deriving a drinking water guideline. Environmental Toxicology, 18, 94-103, 2003   DOI   ScienceOn
6 Kotaki, Y., Tajiri, M., Oshima, Y. and Yasumoto, T. : Identification of calcareous red alga as a primary source of paralytic shellfish toxins in coral reef crabs and gastropods. Bull. Jpn. Soc. Sci. Fish, 49, 283-286, 1983   DOI
7 Negri, A.P., Jones, G.J. and Hindmarsh, M. : Sheep mortality associated with paralytic shellfish poisons from the cyanobacterium Anabaena circinalis. Toxicon, 33, 1321-1329, 1995   DOI   ScienceOn
8 Petzinger, E. : Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion and anionic drug transport. Reviews of Physiology, Biochemistry and Pharmacology, 123, 47- 211, 1994   DOI
9 Saker, M.L., Thomas, A.D. and Norton, J.H. : Cattle mortality attributed to the toxic cyanobacterium Cylindrospermopsis raciborskii in an outback region of North Queensland. Environ Toxicol, 14, 179-182, 1999   DOI
10 Schopf, J.W. : Microfossils of the early Archaen Apex Chert: New evidence of the antiquity of life. Science, 260, 640-646, 1993   DOI   PUBMED   ScienceOn
11 Shaw, G.R., Seawright, A.A., Moore, M.R. and Lam, P.K.S. : Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicological activity. Therapeutic Drug Monitoring, 22(1), 89-92, 2000   DOI   ScienceOn
12 Shaw, G.R., Sukenik, A., Livne, A., Chiswell, R.K., Smith, M.J., Seawright, A.A., Norris, R.L., Eaglesham, G.K. and Moore, M.R. : Blooms of the cylindrospermopsin containing cyanobacterium, Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia. Environ Toxicol 14, 167-177, 1999   DOI
13 Shen, X., Lam, P.K.S., Shaw, G.R. and Wickramasinghe, W. : Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. Toxicon 40(10), 1499-1501, 2002   DOI   ScienceOn
14 Teixeira, M.D.G.L.C., Costa, M.D.C.N., Carvalho, V.L.P.D., Pereira, M.D.S. and Hafe, E. : Gastroenteritis Epidemic in the Area of the Itaparica Dam, Bahia, Brazil. Bulletin of PAHO, 27(3), 244-253, 1993
15 Terao, K., Ohmori, S., Igarashi, K., Ohtani, I., Watanabe, M.F., Harada, K.I., Ito, E. and Watanabe, M. : Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon, 32, 833-843, 1994   DOI   ScienceOn
16 Velzeboer, R.M.A., Baker, P.S., Rositano, J., Heresztyn, T., Codd, G.A. and Raggett, S.L. : Geographical patterns of occurrence and composition of saxitoxin in the cyanobacterial genus Anabena (Nostocales, Cyanophyta) in Australia. Phycologica, 39(5), 395-407, 2000   DOI   ScienceOn
17 Ohtani, I., Moore, R.E. and Runnegar, M.T.C. : Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii. Journal of the American Chemical Society, 114, 7941-7942, 1992   DOI
18 WHO. Cyanobacterial toxins: microcystin-LR. Guidelines for Drinking-water Quality. 2nd ed. Geneva, Switierland: World Health Organisation. P. 95-110, 1998
19 Griffiths, D. and Saker, M. : The Palm Island mystery disease 20 years on: A review of research on the cyanotoxin cylindrospermopsin. Environmental Toxicology, 18(2), 78-93, 2003   DOI   ScienceOn
20 Walter, M.R. : In Early Life on Earth (ed. Bengston, S.) 270-286 (Columbia Univ. Press, New York), 1994
21 Ellegaard Göttingen Minipigs, http://www.minipigs. dk 2005
22 Hawkins, P.R., Runnegar, M.T.C., Jackson, A.R.B. and Falconer, I.R. : Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenya and Subba Raju isolated from a domestic water supply reservoir. Applied and Environmental Microbiology, 50(5), 1292-1295, 1985
23 Jochimsen, E.M., Carmichael, W.W., An, J., Denise, M.C., Cookson, S.T., Holmes, C.E.M., Antunes, M.B.C., Melo, F.D.A., Lyra, T.M., Barreto, V.S.T., Azevedo, S.M.F.O. and Jarvis, W.R. : Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N. Engl. J. Med., 338(13), 873-874, 1998   DOI   ScienceOn
24 Falconer, I.R. : Mechanism of Toxicity of Cyclic Peptide Toxins from Blue-green Algae, Algal Toxins in Seafood and Drinking Water, Chapter 11, 177- 186, Academic Press, 1993
25 Seawright, A.A., Nolan, C.C., Shaw, G.R.,Chiswell, R.K., Norris, R.L., Moore, M.R. and Smith, M.J. : The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska). Environmental Toxicology, 14, 135-142, 1999   DOI
26 Bell, S.G. and Codd, G.A. : Cyanobacterial Toxins and Human Health. Reviews in Medical Microbiology, 5, 256-264, 1994   DOI   ScienceOn
27 Francis, G. : Poisonous Australian Lake. Nature 18, 11-12, 1878
28 Pearce, R.J. and McKenzie, R.A. : Cylindrospermopsis raciborskii (cyanobacterial) poisoning. Vet. Path. Report (ASVP Newsletter), 38, p.18, 1993
29 Australian Drinking Water Guidelines, (NHMRC) ISBN 18649611 8X, 2004
30 Azevedo, S.M.F.O., Carmichael, W.W., Jochimsen, E.M., Rinehart, K.L., Lau, S., Shaw, G.R. and Eaglesham, G.K. : Human intoxication by microcystins during renal dialysis treatment in Caruaru - Brazil. Toxicology, 181-182, 441-446, 2002
31 Codd, G.A. : Cyanobacterial toxins, the perception of water quality and the prioritization of eutrophication control. Ecological Engineering, 16, 51-59, 2000
32 Bourke, A.T.C., Hawes, R.B., Neilson, A. and Stallman, N.D. : An outbreak of hepato-enteritis (the Palm Island Mystery Disease) possibly caused by algal intoxication. Toxicon, Supplement, 3, 45-48, 1983
33 Harada, K., Ohtani, I., Iwamoto, K., Suzuki, M., Watanabe, M.F., Watanabe, M. and Terao, K. : Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method. Toxicon 32(1), 73-84, 1994   DOI   ScienceOn
34 Mez, K., Hanselmann, K., Naegeli, H. and Preisig, H.R. : Protein phosphatase-inhibiting activity in cyanobacteria from alpine lakes in Switerland. Phycologia, 35(6 Supplement), 133-139, 1996   DOI   ScienceOn
35 Thomas, A.D., Saker, M.L. and Olsen, R.D. : Cyanobacterium Cylindrspermopsis raciborskii as a probable cause of death in cattle in Northern Queensland. Australian Veterinary Journal, 76(9), 592-594, 1998   DOI   ScienceOn
36 Fabbro, L.D. and Duivenvoorden, L.J. : Profile of a bloom of the cyanobacterium Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju in the Fitzroy River in tropical central Queensland. Mar. Freshwater Res., 47, 685-694, 1996   DOI   ScienceOn
37 Humpage, A.R., Fenech, M., Thomas, P. and Falconer, I.R. : Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutation Research/ Genetic Toxicology and Environmental Mutagenesis, 472(1-2), 155-161, 2000   DOI   ScienceOn
38 Banker, R.,Teltsch, B., Sukenik, A. and Carmeli, S. : 7-epicylindrospermopsin, a Toxic Minor Metabolite of the Cyanobacterium Aphanizomenon ovalsporum from Lake Kinneret, Israel. J. Nat. Prod., 63, 387- 389, 2000   DOI   ScienceOn
39 Carmichael, W.W., Azevedo, S.M.F.O., An, J.S., Molica, R.J.R., Jochimsen, E.M., Lau, S., Rinehart, K.L., Shaw, G.R. and Eaglesham, G.K. : Human fatalities from cyanobacteria: chemical and biological evidence from cyanotoxins. Environmental Health Perspectives, 109, 663-668, 2001   DOI   ScienceOn
40 Newman, C. : Toxicity Studies with Cyanobacterial Toxins, Diploma Thesis, Friedrich-Alexander University, 2005
41 Stewart, I. : Recreational exposure to freshwater cyanobacteria: Epidemiology, dermal toxicity and biological activity of cyanobacterial lipopolysaccharide, Ph.D Thesis, University of Queensland, 2004