Browse > Article

A Study on the Durability and Synthesis of Sulfa Agents Using Glutaraldehyde  

Yoon Cheol Hun (Department of Chemical Engineering, DaeJin University)
Publication Information
Journal of Environmental Health Sciences / v.30, no.5, 2004 , pp. 374-377 More about this Journal
Abstract
Dual actions are the most recently used delivery system in drug study. Dual-action agents are unique chemical entities comprised of two different type of antibacterial compounds covalently linked together in a single molecule in such a way that both components are able to exert their bactericidal properties. Crosslinked sulfadiazine-sulfanilamide such as antibiotics is synthesized by synthetic handle with glutaraldehyde. As a result, New synthetic antibacterial agent exhibited the broad antibacterial activities against Gram(+) and Gram(-) of 4 strains and a long durability supposing that the stomach and blood.
Keywords
dual action; sulfadiazine; synthetic handle; crosslink agent;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mainardi, J. L. and Shlaes, D. M. : J. Infect. Dis., 171, 1646-1654, 1995   DOI   ScienceOn
2 Albrecht, H. A. : J. Med. Chem., 54, 669-672, 2001.
3 Corraz, A. J. : J. Med. Chem., 35, 1828-1833, 1992.   DOI
4 Bohne, M. H. : Chemotheraphy, 14, 195-211, 1969   DOI   ScienceOn
5 Shkadova, D. K. : Farm. Zh., 24, 39-46, 1969
6 Langer, S. and Wise, D. L. : Medical applications of controlled release, 2, 2-8, CRC Press, Florida, U.S.A, 1994
7 矯本嘉辛 : 藥物送達法, 225-231, 廣川書店, 225-231, 2000
8 Albrecht, H. A. : J. Med. Chem., 53, 77-85, 2000   DOI   ScienceOn
9 Oyrton, A. C., Monteiro, Jr. and Claudio Airoldi : Inter. J. Bio. Macro., 26, 119-125, 1999   DOI   ScienceOn
10 Johnson, P. and Lioyd-Jones, J. G. : Drug delivery systems, 7-18, Ellis Horwood Ltd., England, 1994
11 Poznansky, M. J. : Methods of Drug Delivery, 82-85, Pergamon Press, Oxford, 1996
12 Buurgers, N. A. : Medicinal Chemistry, Part II, 4th ed., 1-5, Wiley Interscience, New York, 1992
13 Guy, R. H. and Hadgraft, J. : Drug parameters imporyant for transdermal delivery. 3, 4-11, CRC Press, Florida, 1997