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http://dx.doi.org/10.5620/eht.2012.27.e2012006

The Prevalence of Atopic Dermatitis, Asthma, and Allergic Rhinitis and the Comorbidity of Allergic Diseases in Children  

Hong, So-Young (Atopy Research Institute, Seoul Medical Center)
Son, Dong-Koog (Atopy Research Institute, Seoul Medical Center)
Lim, Wan-Ryung (Atopy Research Institute, Seoul Medical Center)
Kim, Sun-Hang (Atopy Asthma Center, Seoul Medical Center)
Kim, Hyun-Jung (Atopy Research Institute, Seoul Medical Center)
Yum, Hye-Yung (Atopy Asthma Center, Seoul Medical Center)
Kwon, Ho-Jang (Atopy Research Institute, Seoul Medical Center)
Publication Information
Environmental Analysis Health and Toxicology / v.27, no., 2012 , pp. 6.1-6.8 More about this Journal
Abstract
Objectives: Childhood allergic diseases are a major concern because they lead to a heavy economic burden and poor quality of life. The purpose of this study was to investigate the prevalence of childhood atopic dermatitis, asthma, allergic rhinitis, and the comorbidity of allergic diseases in Seoul, Korea. Methods: We conducted a cross-sectional survey between May and October 2010 to evaluate the prevalence of childhood allergic diseases, including atopic dermatitis, asthma, and allergic rhinitis, using a questionnaire from the International Study of Asthma and Allergies in Childhood group. Each questionnaire was completed by the parent or guardian of a child. Results: In the 31,201 children studied, the prevalence of atopic dermatitis symptoms in the past 12 months was 19.3% in children 0 to 3 years of age, 19.7% in children 4 to 6 years of age, 16.7% in children 7 to 9 years of age, and 14.5% in children 10 to 13 years of age (p for trend < 0.001). The prevalence of asthma in these age groups was 16.5%, 9.8%, 6.5%, and 5.4%, respectively (p for trend < 0.001). The prevalence of allergic rhinitis in these age groups was 28.5%, 38.0%, 38.5%, and 35.9%, respectively (p for trend = 0.043). The percentage of subjects with both atopic dermatitis and asthma, both asthma and allergic rhinitis, or both atopic dermatitis and allergic rhinitis was 2.5%, 4.7%, and 8.7%, respectively. The prevalence of comorbid allergic diseases decreased with age (p for trend < 0.001). Conclusions: Our study revealed that the prevalence of some allergic diseases, such as atopic dermatitis and asthma, was relatively high in very young children and that all of the principal allergic diseases in children often co-exist.
Keywords
Allergic diseases; Allergic rhinitis; Asthma; Atopic dermatitis; Children; Prevalence;
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1 Alsowaidi S, Abdulle A, Bernsen R. Prevalence and risk factors of asthma among adolescents and their parents in Al-Ain (United Arab Emirates). Respiration 2010;79(2):105-111.
2 Demir AU, Celikel S, Karakaya G, Kalyoncu AF. Asthma and allergic diseases in school children from 1992 to 2007 with incidence data. J Asthma 2010;47(10):1128-1135.
3 Chen W, Mempel M, Schober W, Behrendt H, Ring J. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy 2008;63(11):1418-1427.
4 Huurre TM, Aro HM, Jaakkola JJ. Incidence and prevalence of asthma and allergic rhinitis: a cohort study of Finnish adolescents. J Asthma 2004;41(3):311-317.
5 Mitchell VL, Gershwin LJ. Progesterone and environmental tobacco smoke act synergistically to exacerbate the development of allergic asthma in a mouse model. Clin Exp Allergy 2007;37(2):276-286.
6 Ker J, Hartert TV. The atopic march: what's the evidence? Ann Allergy Asthma Immunol 2009;103(4):282-289.
7 Ryan MW. Asthma and rhinitis: comorbidities. Otolaryngol Clin North Am 2008;41(2):283-295.
8 Varonier HS, de Haller J, Schopfer C. Prevalence of allergies in children and adolescents. Helv Paediatr Acta 1984;39(2):129-136 (French).
9 Simpson CR, Newton J, Hippisley-Cox J, Sheikh A. Incidence and prevalence of multiple allergic disorders recorded in a national primary care database. J R Soc Med 2008;101(11):558-563.
10 Nayak AS. A common pathway: asthma and allergic rhinitis. Allergy Asthma Proc 2002;23(6):359-365.
11 O'Regan GM, Irvine AD. The role of filaggrin in the atopic diathesis. Clin Exp Allergy 2010;40(7):965-972.
12 van den Oord RA, Sheikh A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. BMJ 2009;339:b2433.
13 Rodriguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009;123(6):1361-1370.e7.
14 Bonnelykke K, Pipper CB, Tavendale R, Palmer CN, Bisgaard H. Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth. Pediatr Allergy Immunol 2010;21(6):954-961.
15 Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007;62(9):758-766.
16 Strachan D, Sibbald B, Weiland S, Ait-Khaled N, Anabwani G, Anderson HR, et al. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Allergy Immunol 1997;8(4):161-176.
17 Lee SI. Prevalence of childhood asthma in Korea: international study of asthma and allergies in childhood. Allergy Asthma Immunol Res 2010;2(2):61-64.
18 Oh JW, Kim KE, Pyun BY, Lee HR, Choung JT, Hong SJ, et al. Nationwide study for epidemiological change of atopic dermatitis in school aged children between 1995 and 2000 and kindergarten aged children in 2003 in Korea. Pediatr Allergy Respir Dis 2003;13(4):227-237 (Korean).
19 Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007;28(1):3-9.
20 Moonie SA, Sterling DA, Figgs L, Castro M. Asthma status and severity affects missed school days. J Sch Health 2006;76(1):18-24.
21 Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy 2004;34(4):520-526.
22 Kim SY, Yoon SJ, Jo MW, Kim EJ, Kim HJ, Oh IH. Economic burden of allergic rhinitis in Korea. Am J Rhinol Allergy 2010;24(5):e110-e113.
23 Masuda S, Fujisawa T, Katsumata H, Atsuta J, Iguchi K. High prevalence and young onset of allergic rhinitis in children with bronchial asthma. Pediatr Allergy Immunol 2008;19(6):517-522.
24 Zhao J, Bai J, Shen K, Xiang L, Huang S, Chen A, et al. Selfreported prevalence of childhood allergic diseases in three cities of China: a multicenter study. BMC Public Health 2010;10:551.
25 Suh M, Kim HH, Sohn MH, Kim KE, Kim C, Shin DC. Prevalence of allergic diseases among Korean school-age children: a nationwide cross-sectional questionnaire study. J Korean Med Sci 2011;26(3):332-338.
26 Kwon JW, Kim BJ, Song Y, Seo JH, Kim TH, Yu J, et al. Changes in the prevalence of childhood asthma in seoul from 1995 to 2008 and its risk factors. Allergy Asthma Immunol Res 2011;3(1):27-33.
27 Zheng T, Yu J, Oh MH, Zhu Z. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy Asthma Immunol Res 2011;3(2):67-73.
28 Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am 2010;30(3):269-280.
29 Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISSAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009;124(6):1251-1258e23.
30 Kotaniemi-SyrjUanen A, Pelkonen AS, Malmsträsm K, Malmberg LP, Makela MJ. Symptom-based classification of wheeze: how does it work in infants? J Allergy Clin Immunol 2011; 128(5): 1111-1112.e1-e2.
31 Hahn EL, Bacharier LB. The atopic march: the pattern of allergic disease development in childhood. Immunol Allergy Clin North Am 2005;25(2):231-246, v.