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Effects of Platinum Nanoparticles on the Postnatal Development of Mouse Pups by Maternal Exposure  

Park, Eun-Jung (College of Pharmacy, Dongduk Women's University)
Kim, He-Ro (Department of Chemical Engineering, Kwangwoon University)
Kim, Young-Hun (Department of Chemical Engineering, Kwangwoon University)
Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University)
Publication Information
Environmental Analysis Health and Toxicology / v.25, no.4, 2010 , pp. 279-286 More about this Journal
Abstract
Objectives : Platinum nanoparticles (PNPs) are potentially useful for sensing, catalysis, and other applications in the biological and medical sciences. However, little is known about PNP toxicity. In this study, adverse effects of PNPs on the postnatal development of mouse pubs were investigated. Methods : PNPs (size: 20 nm) were prepared and orally administered to mice during premating, gestation, and lactation periods (0.25 mg/kg, 0.5 mg/kg, and 1 mg/kg). Maternal and pup toxicity were evaluated. Results : PNPs did not affect blood biochemical parameters or mortality in dams during the experimental period. Histopathological signs were not observed and pup number was not different between the control and treated groups. Deformity and stillbirth were not observed in the pups. However, PNPs increased pup mortality and decreased the infant growth rate during the lactation period. Conclusion : PNPs may have adverse effects to the postnatal development of mouse pups.
Keywords
Growth rate; Infant mortality; Mice; Platinum nanoparticles; Reproductive toxicity;
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