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Comparison of Distribution and Inflammatory Response by Diameter and Shape of Silver Nanoparticles  

Kim, Soo-Nam (Inhalation Toxicology Center, KIT Jeongeup Campus)
Roh, Jin-Kyu (Department of Chemical Engineering, Kwangwoon University)
Kang, Min-Sung (Inhalation Toxicology Center, KIT Jeongeup Campus)
Han, Young-Ah (Inhalation Toxicology Center, KIT Jeongeup Campus)
Lee, Byoung-Seok (Division of Toxicologic Pathology, Korea Institute of Toxicology)
Kim, Young-Hun (Department of Chemical Engineering, Kwangwoon University)
Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University)
Choi, Kyung-Hee (Department of Risk Assessment, National Institute of Environmental Research)
Park, Eun-Jung (Department of Risk Assessment, National Institute of Environmental Research)
Publication Information
Environmental Analysis Health and Toxicology / v.25, no.3, 2010 , pp. 215-222 More about this Journal
Abstract
The market size of engineered nanoparticles is rapidly increasing due to the fast application of nanotechnologies into different industries and consumer products. The development of new technology and materials has improved human's quality of life, but it also entails the possibility of exposure to new materials. In this study, we compared the distribution in the body by the inflow of silver nanoparticles having another diameter and shape at 1 h or 24 h after injection via the tail vein. And, we compared the cell composition and cytokine concentration in BAL fluid, and histopathological changes. As results, discharge of silver nanoparticles having small diameter and sphere shape was more rapid than that of big diameter or plate shape. It is estimated that the toxicity in liver and lung was proportional to accumulation level. The persistence of inflammation was also longer in mice treated with plate shape. Consequently, we suggest that the first choice of silver nanoparticles having small diameter and sphere shape in applying is desirable.
Keywords
Silver nanoparticles; Distribution; Inflammation; Cytokine; Toxicity;
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Times Cited By KSCI : 1  (Citation Analysis)
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