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Current Uses and Research Activity Regarding Non-testing Methods Including (Q)SARs in Various Chemical Regulatory Programs  

Ha, Mi-Hee (Knowledge Research Group, KIST Europe Forschungsgesellschaft mbH, Saarlandes University)
Kim, Sang-Hun (Knowledge Research Group, KIST Europe Forschungsgesellschaft mbH, Saarlandes University)
Publication Information
Environmental Analysis Health and Toxicology / v.24, no.3, 2009 , pp. 261-270 More about this Journal
Abstract
To make measurable regulatory decisions of chemicals, it is necessary to consider their effect on the human health and ecosystem. In principle, this is based on relevant toxicity studies conducted by accepted guidelines. However, current regulatory programs in various countries confront challenges related to risk assessment of large numbers of chemicals within the restricted resources and time. Therefore there is a need for more efficient approach to limit the number of tests to be conducted. This promotes the development of powerful nontesting methods (e.g. (Q)SARs) and permits to use the predicted data for regulatory purpose. In this article, current status of non-testing methods in various chemical regulatory programs was reviewed in terms of their application and research activity on them. Finally, their usefulness associated with development of domestic regulatory program was suggested.
Keywords
chemicals; regulatory programs; risk assessment; non-testing methods;
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