Browse > Article

Screening Test of Titanium Dioxide Nanoparticles on Blood Coagulation and Platelet Aggregation  

Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University)
Publication Information
Environmental Analysis Health and Toxicology / v.23, no.4, 2008 , pp. 285-290 More about this Journal
Abstract
Effects of titanium dioxide nanoparticles on blood coagulation and platelet aggregation were investigated using diluted whole blood and platelet rich plasma (PRP) solution prepared from human and rat blood, respectively. Blood coagulation was monitored by using a whole blood impedance aggregometer and titanium dioxide nanoparticle (10, 20, and 40 ppm) did not show any effect on the coagulation both in human and in rat blood. When platelet aggregation was measured by turbidometric method after addition of titanium dioxide nanoparticles to PRP solution with final concentrations of 1, 5 and 10 ppm. no aggregation was observed.
Keywords
titanium dioxide nanoparticles; blood coagulation; platelet aggregation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM and Thorne PS. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm, Env Health Perspect 2007; 115: 397-402   DOI
2 Rahman Q, Lohani M, Dopp E, Pemsel H, Jonas L, Weiss DG and Schiffmann D. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts, Environ Health Perspect 2002;110: 797-800   DOI   ScienceOn
3 Seaton A, Soutar A, Crawford V, Elton R, Mcnerlan S, Cherrie J, Watt M, Agius R and Stout R. Particulate air pollution and the blood, Thorax 1999; 54: 1027-1032   DOI   ScienceOn
4 Warheit DB, Hoke RA, Finlay C, Donner EM, Reed K and Sayes CM. Development of a base set of toxicity tests using ultrafine $TiO_2$ particles as a component of nanoparticles risk management, Toxicol Lett 2007; 171: 99-110   DOI   ScienceOn
5 Chen H, Su S, Chien C, Lin W, Yu S, Chou C, Chen J and Yang P. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice, FASEB J 2006; 20: 2393-2395   DOI   ScienceOn
6 Oberdorster G, Oberdoster E and Oberdorster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles, Environ Health Perspect 2005;113: 823-829   DOI   ScienceOn
7 Gelis C, Girard S, Mavon A, Delverdier M, Pailous N and Vicendo P. Assessment of the skin photoprotective cap-acities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models, Photodermatol. Photoimmunol. Photomed. 19; 5: 242-253   DOI   ScienceOn
8 Chan C, Chuang K, Chen W, Chang W, Lee C and Peng C. Increasing cardiopulmonary emergency visits by longrange transported Asian dust storms in Taiwan, Environ Res 2008; 106: 393-400   DOI   ScienceOn
9 Park EJ and Park KS Tissue distribution of $TiO_2$ nanoparticles in mice after oral administration, and skin treatment, J Environ Toxicol 2008c; 23: 63-65   과학기술학회마을
10 Sun D, Meng TT, Loong H and Hwa TJ. Removal of natural organic matter from water using a nano-structured photocatalyst coupled with filtration membrane, Water Sci Technol 2004; 49: 103-110
11 Park EJ, Yi J, Chung KH, Ryu DY, Choi J and Park KS. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells, Toxicol. Lett. 2008b; 180: 222-229   DOI   ScienceOn
12 Radomski A, Jurasz P, Alonso-Escolano D, Drew M, Morandi M, Malinski T and Radomski MW. Nanoparticleinduced platelet aggregation and vascular thrombosis, Brit J Pharmacol 2005; 146: 882-893   DOI   ScienceOn
13 Park EJ, Choi J, Park Y and Park K. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B Cells, Toxicology 2008a; 245: 90-100   DOI   ScienceOn
14 Nemmar A, Hoet APHM, Dinsdale D, Vermylen H, Mortelmans L, Nemery B. Passage of inhaled particles into the blood circulation in humans, Circulation 2002; 105:411-414   DOI   ScienceOn
15 Roy SC, Paulose M and Grimes CA. The effect of $TiO_2$ nanotubes in the enhancement of blood clotting for the control of hemorrhage, Biomaterials 2007; 28: 4667-4672   DOI   ScienceOn
16 Niwa Y and Iwai N. Nanomaterials induce oxidized lowdensity lipoprotein cellular uptake in macrophages and platelet aggregation, Cir J 2007; 71: 437-444   DOI   ScienceOn
17 Wang JM, Xiao BL, Zheng JW, Chen HB and Zou SO. Effect of targeted magnetic nanoparticles containing 5-FU on expression of bcl-2, bax and caspase-3 in nude mice with transplanted human liver cancer, World J Gastroenterol 2007; 13: 3171-3175   DOI