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Tissue Distribution of $SiO_2$ Nanoparticles in Mice after Oral Administration or Skin Treatment  

Park, Eun-Jeung (College of Pharmacy, Dongduk Women's University)
Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University)
Publication Information
Environmental Analysis Health and Toxicology / v.23, no.2, 2008 , pp. 139-141 More about this Journal
Abstract
Tissue distribution of $SiO_2$ nanopaprticles was investigated in mice after oral administration or skin treatment. ICR Male mice were treated with $SiO_2$ nanoparticles 2.5 g/kg/day for five consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered $SiO_2$ nanoparticels were distributed in the testis and kidney but not in lung at 24 hours after the last treatment. In case of skin treatment, $SiO_2$ nanoparticles were distributed to lung as well as testis, brain, kidney and liver. The results suggested that $SiO_2$ nanoparticles (12 nm) are easily absorbed through entero-gastric system or skin.
Keywords
$SiO_2$ nanoparticles; tissue distribution; brain; testis; kidney; liver;
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