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Exposure Monitoring of Nonylphenol in Preterm Breast milk in Seoulers  

Yi, Bit-Na (Sookmyung Women's University College of Pharmacy)
Kim, Chang-Sung (Korea Testing & Research Institute)
Park, Mi-Jung (Inje University Sanggye Paik Hospital)
Han, Yu-Sok (Sungse Children's Hospital)
Lee, So-Jung (Sookmyung Women's University College of Pharmacy)
Yan, Mi-Hi (Sookmyung Women's University College of Pharmacy)
Publication Information
Environmental Analysis Health and Toxicology / v.23, no.2, 2008 , pp. 113-117 More about this Journal
Abstract
Biomonitoring of nonylphenol (NP), an endocrine disrupting chemical, is required in Korea to perform its proper regulation. Thus, we analyzed exposure levels of nonlyphenol (NP) in breast milk from the mothers who delivered babies within 10 days (N=325). We analyzed free and total forms of NP in breast milk with LC/MS/MS (LOD, 0.5 ppb). In addition, we obtained questionnaires concerning lifestyle from the subject. As results, ranges of total NP were (median, vs. normal, N=281, $2.07{\pm}3.76{\mu}g/L$; p<0.05). In conclusion, we suggest that exposure monitoring of NP should be continuously performed, even though the risks of NP are not clear, yet.
Keywords
Nonylphenol; milk; endocrine disrupting chemicals; Korean; biomonitoring;
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1 Atiezar FA, Billinghust Z and Depledge MH. 4-n-nonylphenol and 17-${\beta}$ estradiol may induced common DNA effects in developing barnacle larvae, Environmental Pollution 2002; 120: 735-738   DOI   ScienceOn
2 Bromwich P, Cohen J, Stewart I and Walker A. Decline in sperm counts : an artifact of changed reference range of 'normal'?, British Med Journal 1994; 309: 19-22   DOI   ScienceOn
3 Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, and Needham LL. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population, Environ. Health Perspect 2005; 113(4): 391-395   DOI   ScienceOn
4 Recchia AG, Vivacqua A, Garpino A, Fasanella G, Rago V, Bonofoglio D and Maggiolini M. Xenoestrogens and the induction of proliferative effects in breast cancers via direct activation of oestrogen receptor alpha, Food addict contamination 2004; 21: 133-144
5 Vivacqua A, Recchia AG, Fasanella G, Garpino A, Rago V, Di Gioia ML, Leggio A, Bonofiglio D, Maggiolini M and Liguori A. The food contaminations bisphenol A and nonylphenol act as agonists for estrogen receptor alpha in MCF breast cancer cells, Endocrine 2003; 22: 275-284   DOI   ScienceOn
6 Ye X, Kuklenvik Z, Needham LL and Calafat AM. Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography- isotope dilution tandem mass spectrometry, Journal of Chromatography B 2006; 831: 110-115   DOI   ScienceOn
7 Safe SH. Endocrine disruptors and human health-is there a problem? An update, Environ. Health Perspect 2000; 108: 487-493   DOI
8 Sharpe RM. Hormones and testis development and the possible adverse effects of environmental chemicals, Toxicol Lett 2001; 120: 221-232   DOI   ScienceOn
9 Sonnenschein C and Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists, J Steriod Biochem Mol Biol 1998; 65: 143-150   DOI   ScienceOn
10 Otaka H, Yasuhara A and Morita M. Determination of bisphenol A and 4-nonylphenol in human milk using alkaline digestion and cleanup by solid-phase extraction. Anal Sci 2003; 19: 1663-1666   DOI   ScienceOn
11 Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM and vom Saal FS. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity, Environ. Health Perspect 2003; 111: 994-1006   DOI   ScienceOn
12 Daidoji T, Ozawa M, Sakamoto H, Sako T, Inoue H and Kurihara R. Slow elimination of nonylphenol from rat intestine, Drug Metabol Dispos 2006; 34(1): 184-190   DOI   ScienceOn
13 이창주, 윤용달. 내분비계장애물질이 생식과 발생에 미치 는 영향, 한국발생생물학회지 2002; 4(2): 3-11
14 Yang M, Park MS and Lee HS. Endocrine disrupting chemicals: human exposure and health risks, J Eviron Sci Health C Environ Carcinogen Ecotoxicol Rev 2006; 24: 188-224
15 Solomon GM and Weiss PM. Chemical contaminants in breast milk : time trends and regional variability, Environ Health Perspect 2002; 110: A339-348   DOI
16 환경부, 환경백서 2007; 627
17 Kahl MD, Makynen EA, Kosian PA and Ankley GT. Toxicity of 4-nonylphenol in a life-cycle test with the midge Chironomus tentans, Ecotoxicol Environ Safe 1997; 38: 155-160   DOI   ScienceOn
18 Neville MC, Keller R, Seacat J, Lutes V, Neifert M, Casey C, Alleln J and Archer P. Studies in human lactation : milk volumes in lactating women during the onset of lactation and full lactation, Am J Clin Nutr 1988; 48: 1375- 1386   DOI
19 Sumpter JP. Xenoendocrine disruptores-environmental impacts, Toxicol Lett 1998; 102-103: 337-342   DOI   ScienceOn
20 Calafate AM, Ye X, Silva MJ, Kuklenyik Z and Needham LL. Human exposure assessment to environmental chemicals using biomonitoring, International Journal of Andrology 2006; 29: 166-171   DOI   ScienceOn
21 Hooper K and MacDonald TA. The PBPEs : an emerging environmental challenge and another reason for breastmilk monitoring programs, Environ. Health Perspect 2000; 108: 387-392   DOI
22 Colborn T, Vom Saal FS and Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans, Environ. Health Perspect 1993; 101: 378-384   DOI
23 Sonowane BR. Chemical contaminants in human milk : An overview, Environ Health Perspect 1995; 103: 197-205   DOI