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Tissue Distribution of $TiO_2$ Nanoparticles in Mice after Oral Administration, and Skin Treatment  

Park, Eun-Jung (College of Pharmacy, Dongduk Women's University)
Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University)
Publication Information
Environmental Analysis Health and Toxicology / v.23, no.1, 2008 , pp. 63-65 More about this Journal
Abstract
The tissue distribution of $TiO_2$, nanopaprticles was investigated in mice after oral administration, and skin treatment. Male mice were treated with the dose of 5 g/kg of $TiO_2$ for three consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered $TiO_2$ nanoparticels were shown to be distributed in the testis, lung, and brain at 24 hours after the last treatment. Kidney does not seem to be the main target of $TiO_2$ nanoparticle distribution. It means that $TiO_2$ nanoparticles (17 nm) are easily absorbed through entero-gastric system and may cause toxicity in brain, lung, and reproductive organs. The distribution of skin treatment showed the same pattern like oral administration.
Keywords
$TiO_2$ nanoparticles; tissue distribution; lung; brain; testis;
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1 Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM and Thorne PS. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm, Env Health Persp 2007; 115(3): 397-402   DOI
2 Sun D, Meng TT, Loong H and Hwa TJ. Removal of natural organic matter from water using a nano-structured photocatalyst coupled with filtratin membrane, Water Sci Tech-nol 2004; 49: 103-110
3 Chen H, Su S, Chien C, Lin W, Yu S, Chou C, Chen J and Yang P. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice, FASEB J 2006; 20: 2393-2395   DOI   ScienceOn
4 Oberdorster G, Oberdoster E and Oberdorster J. Nanotoxicology:An emerging discipline evolving from studies of ultrafine particles, Environ Health Perspect 2005; 113(7):823-829   DOI   ScienceOn
5 Warheit DB, Hoke RA, Finlay C, Donner EM, Reed K and Sayes CM. Development of a base set of toxicity tests using ultrafine $TiO_2$ particles as a component of nanoparticles risk management, Toxicol Lett 2007; 171: 99-110   DOI   ScienceOn
6 Park EJ, Choi J, Park YK and Park K. Oxidative stress Induced by cerium oxide nanoparticles in cultured BEAS-2B cells, Toxicology 2008; 245/1-2: 90-100   DOI   ScienceOn
7 Wangs J, Zhou G, Chen C, Yu H, Wans T, Ma Y, Jia G, Gao Y, Li B, Sun J, Li Y, Jiao F, Zhao Y and Chai Z. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration, Toxicol Lett 2007; 168: 176-185   DOI   ScienceOn
8 Gelis C, Girard S, Mavon A, Delverdier M, Pailous N and Vicendo P. Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models, Photodermatol Photoimmunol Photomed 2003; 19(5): 242-253   DOI   ScienceOn