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Effect of Genotoxicity or Carcinogenecity Chemicals on the ROS Production  

Go, Seo-Youn (College of Pharmacy, Ewha Womans University)
Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
Publication Information
Environmental Analysis Health and Toxicology / v.23, no.1, 2008 , pp. 23-32 More about this Journal
Abstract
In the present study, ROS detection of L5178Y cells that were treated with twenty test compounds in order to find out hydrogen peroxide ($H_2O_2$) induction for genotoxicity and carcinogenic toxicity. Twenty test compounds were consist of four classes, such as genotoxic carcinogens, genotoxic noncarcinogens, nongenotoxic carcinogens, and nongenotoxic noncarcinogens. Genotoxic carcinogens are 1,2-dibromoethane, glycidol, melphalan, diethylstilbestrol and urethane. Genotoxic noncarcinogens are 8-hydroxyquinoline, emodin, acetonitrile and diallylphthalate, L-ascorbic acid. Nongenotoxic carcinogens are methyl carbamate, O-nitrotoluene, 1,4-dioxane, tetrachloroethylene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. And nongenotoxic noncarcinogens are D-mannitol, 1,2-dichlorobenzene, caprolactam, bisphenol A and chlorpheniramine maleate.
Keywords
genotoxicity; carcinogenicity; oxidative stress; hydrogen peroxide ($H_2O_2$; );
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