Cadmium-induced COX-2 Expression in Cerebrovascular Endothelial Cells
![]() |
Park Dong-Hyun
(Department of Physiology, Ajou University School of Medicine)
Kim Young-Chae (Department of Physiology, Ajou University School of Medicine) Moon Chang-Kiu (College of Pharmacy, Seoul National University) Jung Yi-Sook (Department of Physiology, Ajou University School of Medicine) Baik Eun-Joo (Department of Physiology, Ajou University School of Medicine) Moon Chang-Hyun (Department of Physiology, Ajou University School of Medicine) Lee Soo-Hwan (Department of Physiology, Ajou University School of Medicine) |
1 | Andersson H, Petersson-Grawe K, Lindqvist E, Luthman J, Oskarsson A and Olson L. Low level cadmium exposure of lactating rats causes alterations in brain serotonin levels in the offspring. Neurotoxicol. Teratol. 1997; 19: 105-115 DOI ScienceOn |
2 | Berglund M, Akesson A, Bjellerup P and Vahter M. Metalbone interactions. Toxicol. Lett. 2000; 15: 112-113:219-225 |
3 | Elliott P, Arnold R, Cockings S, Eaton N, Jarup L, Jones J, Quinn M, Rosato M, Thornton I, Toledano M, Tristan E and Wakefield J. Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium. Occup. Environ. Med. 2000; 57(2): 94-97 DOI |
4 | Fang X, Moore AS, Nwankwo JO, Weintraub LN, Oberley WL, Snyder DG and Spector AA. Induction of cyclooxygenase-2 by overexpression of the human catalase gene in cerebral microvascular endothelial cells. J. Neurochem. 2000; 75(2): 614-623 DOI |
5 | Jeong EM, Moon CH, Kim CS, Lee SH, Baik E.J, Moon CK and Jung YS. Cadmium stimulates the expression of ICAM-1 via NF-B activation in cerebrovascular endothelial cells. Biochem. Biophys. Res. Commun. 2004; 320: 887-892 DOI ScienceOn |
6 | Kim SJ, Im DS, Kim SH, Ryu JH, Hwang SG, Seong JK, Shun CH and Chun JS. Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes. Biochem. Biophys. Res Commun. 2002; 296(1): 221-226 DOI ScienceOn |
7 | Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol. 2004; 63: 901-910 DOI |
8 | Nogawa S, Zhang F, Ross ME and Iadecola C. Cyclooxygenase- 2 gene expression in neuronscon-tributes to ischemic brain damage. J. Neurosci. 1997; 17: 2746-2755 DOI |
9 | Rockwell P, Martinez J, Papa L and Gomes E. Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium. Cell Signal. 2004; 16: 343-353 DOI ScienceOn |
10 | Zhang F, Hackett NR, Lam G, Cheng J, Pergolizzi R, Luo L, Shmelkov SV, Edelberg J, Crystal RG and Rafii S. Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells. Blood 2003; 102(6): 2115-2121 DOI ScienceOn |
11 | Zimmerhackl LB, Momn F, Wiegele G and Brandis M. Cadmium is more toxic to LLC-PKl cells than to MDCK cells acting on the cadherine-catenin complex. Am. J. Physiology 1998; 275 (1 Pt 2): F143-154 |
12 | Seok SM, Park DH, Kim YC, Moon CH, Jung YS, Baik EJ, Moon CK and Lee SH. COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovas-cular endothelial cells. Toxicol. Lett. 2006; 165: 212-220 DOI ScienceOn |
13 | Hart RP, Rose CS and Hamer RM. Neuropsychological effects of occupational exposure to cadmium. J. Clin. Exp. Neuropsychol. 1989; 11: 933-943 DOI |
14 | Iadecola C and Alexander M. Cerebral ischemia and inflammation. Curr. Opin. Neurol. 2001; 14: 89-94 DOI ScienceOn |
15 |
Pourahmad J and O′Brien PJ. A comparison of hepatocyte cytotoxic mechanisms for |
16 | Wyss-Coray T and Mucke L. Inflammation in neurodegenerative disease-a double-edged sword. Neuron 2002; 35: 419-432 DOI ScienceOn |
17 |
Qanungo S, Wang M and Nieminen AL. N-Acetyl-Lcysteine enhances apoptosis through inhibition of nuclear |
18 | Romare A and Lundholm CE. Cadmium-induced calcium release and prostaglandin E2 production in neonatal mouse calvaria are dependent on COX-2 induction and protein kinase C activation. Arch. Toxicol. 1999; 73: 223-228 DOI |
19 | Stohs SJ, Bagchi D, Hassoun E and Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 2000; 19: 201-213 |
20 | Bush KT, Goldberg AL and Nigam SK. Proteaspme inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J. Biol. Chem. 1997; 272(14): 9086-9092 DOI ScienceOn |
21 | Laporte JD, Moore PE. Lahiri T, Schwartzman IN, Panettieri RA Jr and Shore SA. p38 MAP kinase regulates IL-1 beta responses in cultured airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2000; 279(5): L932-941 |
22 | Figueiredo-Pereira ME, Li Z, Jasen M and Rockwell P. N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 upregulation in mouse neuronal cells. J. Biol. Chem. 2002; 277: 25283-25289 DOI ScienceOn |
23 | Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S and Ross ME. Reduced susceptibility to ischemic brain injury and NMDA-mediated neurotoxicity in cyclooxygense deficient mice. Proc. Natl. Acad. Sci. USA. 2001; 98: 1294-1299 |
24 | Xu J, Maki D and Stapleton SR. Mediation of cadmiuminduced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion. J. Biochem. Mol. Toxicol. 2003; 17: 67-75 DOI ScienceOn |
25 |
Gallois C, Habib A, Tao J, Moulin S, Maclouf J, Mallat A and Lotersztajn S. Role of |
26 | Shukla A, Shukla GS and Srimal RC. Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat. Hum. Exp. Toxicol. 1996; 15: 400-405 DOI |
27 | Okuda B, Iwamoto Y, Tachibana H and Sugita M. Parkinsonism after acute cadmium poisoning. Clin. Neurol. Neurosurg. 1997; 99: 263-265 DOI ScienceOn |
28 | Ramirez DC and Gimenez MS. Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages. Toxicol. Lett. 2003; 145: 121-132 DOI ScienceOn |
![]() |