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The Distribution of TaqI RFLP in the Vitamin D Receptor Gene in Korean Vegetarian Men and its Association with Calcaneal Bone Mineral Density  

Kang Byung-Yong (Research Institute for Life Science, Sahmyook University)
Kim So-Yeon (Department of Health and Social Welfare, Sahmyook Nursing and Health College)
Lee Sang-Jin (Department of Animal Science, Sahmyook College)
Kim Hyun-Hee (Department of Life Science, Sahmyook University)
Publication Information
Environmental Analysis Health and Toxicology / v.21, no.1, 2006 , pp. 27-34 More about this Journal
Abstract
Numerous studies reported the significant association between genetic polymorphisms in the vitamin D receptor (VDR) gene and various bone phenotypes such as bone mineral density (BMD) and bone quality, although conflicting results were produced. The objective of this study was to investigate the association between a TaqI RFLP in the VDR gene and calcaneal BMD in Korean vegetarian men, and its interaction with nutrition status as an environmental factor. BUA (broadband ultrasound attenuation), SOS (sound of speed) and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 266 Korean men (age: $mean{\pm}SD;\;50.9{\pm}12.0$ year), and a TaqI RFLP in the VDR gene analysed by PCR-RFLP method. In total subjects, the distribution of TT, Tt and tt genotypes occurred with frequencies of 90.8%, 8.8% and 0.4%, respectively. There were no significant associations between this polymorphism and osteopenia-osteoporosis or several bone phenotypes in our subjects irrespectively of nutrition status (P>0.05). Therefore, our results suggest that a TaqI RFLP in the vitamin D receptor gene does not contribute to the susceptibility to the calcaneal BMD in Korean men.
Keywords
calcaneus; vitamin D receptor and vegetarian;
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