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Potential Risk to Human Health by Arsenic and Its Metabolite  

Bae Ok-Nam (College of Pharmacy, Seoul National University)
Lee Moo-Yeol (College of Pharmacy, Seoul National University)
Chung Seung-Min (College of Pharmacy, Seoul National University)
Ha Ji-Hye (College of Pharmacy, Seoul National University)
Chung Jin-Ho (College of Pharmacy, Seoul National University)
Publication Information
Environmental Analysis Health and Toxicology / v.21, no.1, 2006 , pp. 1-11 More about this Journal
Abstract
Arsenic is a ubiquitous element found in several forms in environment. Although certain foods, such as marine fish, contain substantial levels of organic arsenic forms, they are relatively low in toxicity compared to inorganic forms. In contrast, arsenic in drinking water is predominantly inorganic and very toxic. Chronic ingestion of arsenic-contaminated drinking water is therefore the major pathway posing potential risk to human health. World populations are exposed to low to moderate levels of arsenic of parts per billion (ppb) to thousands of ppb. When exposed to human, it could metabolize into monomethylarsonous acid ($MMA^{III}$) and dimethylarsinous acid ($DMA^{III}$) which are highly toxic. Lots of stuides have been recently focused how $MMA^{III}\;and\;DMA^{III}$ induce toxic insults in various target tissues. Epidemiological studies revealed that chronic arsenic exposure caused cancer, cardiovascular diseases, and diabetes etc. In this review, the current understanding of arsenic on health effects will be discussed.
Keywords
arsenic; monomethylarsonous acid ($MMA^{III}$)dimethylarsinous acid ($DMA^{III}$); drinking water; human health;
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