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Slow-Stirring Methods for Determining the n-Octanol/Water Partition Coefficient(Pow) of Highly Hydrophobic Chemicals  

Chang Hee Ra (Environmental Toxicology division, Korea Institute of Toxicology, KRICT)
Lee Bong Jae (Environmental Toxicology division, Korea Institute of Toxicology, KRICT)
Kim Kyun (Environmental Toxicology division, Korea Institute of Toxicology, KRICT)
Kim Yong Hwa (Environmental Toxicology division, Korea Institute of Toxicology, KRICT)
Publication Information
Environmental Analysis Health and Toxicology / v.20, no.4, 2005 , pp. 351-358 More about this Journal
Abstract
The n -octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemiral's environmental fate and toxicity. The shake-flask method, one direct experimental method, i.1 prone to experimental artifacts for highly hydrophobic compounds. Thus, a valid method for direct determination of the Pow of highly hydrophobic compounds is needed. The slow -stirring method has been demonstrated to provide reliable log Pow data to log Pow greater than 5. This study was performed to evaluate the accuracy of slow- stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. 1, 2, 3, 4-tetrachlorobenzene, hexachlorobezene, 2, 2', 3, 3', 5, 5', 6, 6'-octachlorobiphenyl, decachlorobiphenyl, and p, p'-DDT (4.50.02, 5.41$\times$0.06, 7.26$\times$0.04, 7.87$\times$0.10, and 6.03$\times$0.06, respectively. The octanol/water partition coefficient by the slow-stirring method were very similar to the literature values. These results indicate that the slow- stirring method allows for reliable determination of log Pow of highly hydrophobic chemicals.
Keywords
Slow-stirring method; Hydrophobic chemicals; Octanol/water partition coefficient;
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