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The Mechanism of the Neurotoxicity Induced by Cadmium  

Lee Jong-Wha (순천향대학교 환경보건학과)
Jang Bong-Ki (순천향대학교 환경보건학과)
Park Jong-An (순천향대학교 환경보건학과)
Park Jong-Young (순천향대학교 환경보건학과)
Kim Wan-Jong (순천향대학교 생물학과)
Woo Ki-Min (순천향대학교 의과대학 생화학교실)
Publication Information
Environmental Analysis Health and Toxicology / v.19, no.3, 2004 , pp. 279-286 More about this Journal
Abstract
Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system, the mechanism of toxicity is not well understood. The present study has investigated the effect of cadmium on oxidative stress, Na$^{+}$K$^{+}$ ATPase activity and the aggregation of amyloid beta peptide ($\beta$-amyloid) in neuronal cell line, HT22 cell. LC$_{5}$ and LC$_{50}$ of cadmium for HT22 cell resulted from MTT assay was 4.1 uM and 9.5 uM, respectively. Cadmium (2 to 8 uM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione. Cadmium 4 uM showed a significant decrease in Na$^{+}$/K $^{+}$ ATPase activity as compared with control group. The aggregation of $\beta$-amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 uM cadmium. These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na$^{+}$/K$^{+}$ ATPase activity.se activity.
Keywords
cadmium; lipid peroxidation; glutathione; Na$^{}$ +//K$^{}$ +/ ATPase; ${\beta}$-amyloid;
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