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Effects of Subacute Oral Administration of Bisphenol A on the IgM-PFC and Proliferation of Splenocytes in Mice  

변정아 (숙명여자대학교 약학대학)
표명윤 (숙명여자대학교 약학대학)
Publication Information
Environmental Analysis Health and Toxicology / v.18, no.3, 2003 , pp. 231-235 More about this Journal
Abstract
To determine whether or not bisphenol A affects the Immune system, female ICR mice were treated bisphenol A (BPA) orally at the doses of 100, 500 and 1,000 mg/kg for 30 consecutive days. Four days before enumerating Plaque -forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells (SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30-day exposure to BPA (1,000 mg/kg/day), but the PFC/10$\^$6/ spleen cells was slightly decreased.. When splenocytes isolated from the mice exposed to BPA for 30 days were cultured in the presence of LPS, Con A or PHA with IL-2, the lymphocyte proliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-day exposure of mice to BPA might have mild immunotoxic potential.
Keywords
Bisphenol A; IgM-PFC; splenic proliferation;
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1 Kang J and Kondo F. Determination of bisphenol A in canned pet foods. Res Vet Sci, 2002; 73(2): 177-183   DOI   ScienceOn
2 Sakurai H, Maeda M, Miyahara K, Nakayama M, Murayama H, Hasegawa H, Hayakawa M, Sugiura T and Kamikura K. Extraction of bisphenol-A from a cardiopulmonary bypass circuit. Kyobu Geka, 2002; 55(9): 770-772
3 Tallarida RJ and Murray RB. Manual of Pharmacologic calculations with computer programs, 1981; Springer-Verlag
4 Dechaud H, Ravard C, Claustrat F, Aude Brae de la perriere and Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids, 1999; 64: 328-334   DOI   ScienceOn
5 Dolye A, Griffiths JB and Newell DG. Cell & Tissue Culture; Laboratory procedures, 1993; John Wiily & Sons Ltd., U.K
6 Farabollini F, Porrini S, Seta DD, Bianchi F and Dessi-Fulgheri F. Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats. Environmental Health Perspectives, 2002; 110(suppl 3): 409-414   DOI
7 Olea N, Pulgar R, Perez P, Olea-Serrano F, Rivas A, Novillo-Fertrell A, Pedreaza V, Soto AM and Sonnens-chein C. Estrogenecity of resinbased composites and sealants used in dentistry. Environmental Health perspectives, 1996; 104(3): 298-305   DOI   ScienceOn
8 Deyo JA and Kerkvliet NI. Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subcronic administration to C57B1/6 mice. Fundam. Appl. Taxicol., 1990; 14: 842-849   DOI   ScienceOn
9 Hiliard CA, Armstrong MJ, Bradt CI, Hill RB, Greenwood SK and Galloway SM. Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals (nd metabolic poisons. Environmenatal and molecular mutagenesis, 1998; 31: 316-326   DOI   ScienceOn
10 Mishell RI and Dutton RW. Immunization of normal mouse spleen cell suspensions in vitro. Science., 1966; 153: 1004-1005   DOI   PUBMED   ScienceOn
11 Chen MY, Ike M and Fujita M. Acute toxicity, Mutagenicity, and Estrogenecity of Bisphenol-A and other bisphenols. Environ. Toxicol, 2002; 17: 80-86   DOI   ScienceOn
12 Krishnan AV, Stathis P, Permuth SF, Tokes L and Feldman D. Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endo. 1993; 132: 2279-2286   DOI
13 Goodson A, Summerfield W and Cooper I. Survey of bis-phenol A and bisphenol F in canned foods. Food Addit Contam, 2002; 19(8): 796-802   DOI   ScienceOn
14 Cunningham A and Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. 1968; Immunol., 14: 599-600
15 EPA-Health Effects Test Guidelines-Immunotoxicity (1996)
16 표명윤, 변정아. Bisphenol A의 급성노출이 마우스의 면역 기능에 미치는 영향. 약학회지 2001; 45(1): 55-63
17 Morrissey RE, George JD, Price CJ, TYL RW, Marr MC and Kimmel CA. The developmental toxicity of bisphenol A in rats and mice. Fundam. Appl. Toxicol., 1987; 8: 571-582   DOI   ScienceOn
18 Mountfort KA, Kelly J, Jickells SM and Castle L. Investigations into the potential degradation of polycarbonate baby bottles during sterilization with consequent release of bisphenol A. Food Addit Contam, 1997; 14(6-7): 737-740   DOI
19 Papaconstantinou AD, Umbreit TH, Fisher BR, Goering PL, Lappas NT and Brown KM. Bisphenol A-induced increase in uterine weight and alteration in uterine morphology in ovariectomized B6C3FI mice: role of the estrogen receptor. Toxicol Sci., 2000; 56: 332-339   DOI   ScienceOn