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Reduction of Chromium (Ⅵ) and Carcinogenesis  

박형숙 (한서대학교 환경공학과)
Publication Information
Environmental Analysis Health and Toxicology / v.18, no.3, 2003 , pp. 165-174 More about this Journal
Abstract
Cr (Ⅵ) - containing compounds are well-established carcinogens, although the mechanism for chromium - induced carcinogenesis is still not well understood. The reduction of Cr (Ⅵ) to its lower oxidation states, par ticularly Cr (V) and Cr (IV), is an important step for the production of chromium-mediated reactive oxygen species (ROS). The persistent oxidative stress during the reduction process may play a key role in the mechanism of Cr (Ⅵ) -induced carcinogenesis. This paper summarizes recent studies on (1) the reduction of Cr (Ⅵ) to Cr (III) occur by a multiplicity of mechanisms depending on the nature of reducing agents including ascorbate, diol-and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) free radical - induced cellular damage, such at DNA strand breaks, hydroxylation of 2'-deoxyguanosine, and activation of nuclear transcription factor kB.
Keywords
Cr(VI); reduction; carcinogenesis; reactive oxygen species; oxidative stress;
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1 Freund H, Altamian S and Fischer JE. Chromium deficiency during total parenteral nutrition, J. American Med. Asso. 1979; 241: 496-498   DOI   ScienceOn
2 Hayes RB. Review of occupational epidemiology of chromium chemicals and respiratory cancer, Sci. Total Environ. 1988; 71: 331-339   DOI   ScienceOn
3 Lehmann KB. 1st grund zu einer besonderen Beunruhigung wegen des Auftretens von Lungenkrebs bei Chromatarbeitern vorhaden?, Zentralbl Gewerbehyg 1932; 19: 168 -170. Cited in: Langard S. One hundred years of chromium and cancer: A review of epidemiological evidence and selected case reports, Ame. J. Indus. Med. 1990; 17: 189-215   DOI   ScienceOn
4 Liu KJ, Shi X, Jiang JJ, Goda F, Dalal NS and Swartz HM. Low frequency electron paramagnetic resonance investigation on metabolism of chromium (VI) by whole mice, Annu. Clin. Lab. Sci. 1996; 26: 176- 184
5 Saner G. Chromium in nutrition and Disease-Current Topics in Nutrition and Disease. Alan R. Liss, New York 1980; 2: 26-29
6 Shi X and Dalal NS. The mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr (V) intermediate, Biochem. Biophys. Res. Commun. 1988; 156: 137-142   DOI   ScienceOn
7 Shi X, Dalal NS and Kasprzak KS. Generation of free radicals from hydrogen peroxide and lipid hydroperoxidesin the presence of Cr (III), Arch. Biochem. Biophys. 1993; 302: 294-299   DOI   ScienceOn
8 Shi X, Mao Y, Knapton AD, Ding M, Rojanasakul Y, Gannett PM, Dalal NS and Liu K. Reaction of Cr (VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: Role of Cr (lV)-mediated Fenton-like reaction, Carcinogenesis 1994; 15: 2475-2478   DOI   ScienceOn
9 Suzuki Y and Fukuda K. Reduction of hexavalent chromium by ascorbic acid and glutathione with special reference to the rat lung, Arch. Toxicol. 1990; 64: 169-176   DOI   ScienceOn
10 Lefebvre Y and Pezerat H. Production of activated species of oxygen during the chromate (VI)-ascorbate reaction: Implication in carcinogenesis, Chem. Res. Toxicol. 1992; 5: 461-463   DOI   ScienceOn
11 Liebross RH and Wetterhahn KE. In vivo formation of chromium (V) in chick embryo red blood cells, Chem. Res. Toxicol. 1990; 3: 401-403   DOI   ScienceOn
12 Sunderman FW Jr. Metals and lipid peroxidation, Acta Pharmacol. Toxicol. 1986; 59: 248-255   DOI
13 Baldwin AS. The NF-$\kappa B$ and 1$\kappa B$ proteins: New discoveries and insights, Annu. Rev. Immunol. 1996; 14: 640-681
14 IARC. Monograph on the Evaluation of Carcinogenic Risk to Humans: Chromium, Nickel and Welding. Lyon, International Agency for Research on Cancer 1990; 49
15 Sugiyama M, Tsuzuki K, Hidaka T, Yamamoto M and Ogura R. Reduction of chromium-(VI) in Chinese hamster V-79 cells, Biol. Trace Elem. Res. 1991a; 30: 1-9   DOI   ScienceOn
16 Granger DN, Hollwarth MA and Parks DA. Ischemia reperfusion injury: Role of oxygen-derived free radicals, Acta Physiol. Scand. 1982; 126: Suppl. 548: 47-63
17 Liu K, Jiang J, Swartz HM and Shi X. Low frequency ESR detection of chromium (V) formation by one-electron reduction of chromium (VI) in whole live mice, Arch. Biochem. Biophys. 1994; 313: 248-252   DOI   ScienceOn
18 Sugiyama M, Tsuzuki K, Lin X and Costa M. Potentiation of sodium chromate (VI)-induced chromosomal aberrations and mutations in Chinese hamster V-79 cells, Mutat. Res. 1992; 283: 211-214   DOI   ScienceOn
19 DeFlora S and Wetterhahn KE. Mechanism of chromium metabolism and genotoxicity, Life Chem, Rep. 1989; 7: 169-244
20 Dizadaroglu M. Chemical determination of free radicalinduced damage to DNA, Free Radical Biol. Med. 1991; 10: 225-242   DOI   ScienceOn
21 Sugiyama M, Tsuzuki K and Haramaki N. Influence of ophenanthroline on DNA single-strand breaks, alkali-lable sites, glutathione reductase, and formation of chro-mium (V) in Chinese hamster V-79 cells treated with sodium chromate (VI), Arch. Biochem. Biophys. 1993; 305: 261-266   DOI   ScienceOn
22 Standeven AM and Wetterhahn KE. Ascorbate is the principal reductant of chromium (VI) in rat lung ultrafiltrates and cytosols, and mediates chromium-DNA binding in vitro, Carcinogenesis 1992; 13: 1319-1324   DOI   ScienceOn
23 O'Brien P, Barrett J and Swanson F. Chromium (V) can be generated in the reduction of chromium (VI) by glutathione, Inorg. Chim. Acta. 1985; 108: L19-L20   DOI   ScienceOn
24 Ye J, Zhang X, Young HA, Mao Y and Shi X. Chromium (VI)-induced nuclear factor-$\kappa B$ activation in intact cells via free radical reactions, Carcinogenesis 1995; 16: 2401-2405   DOI   ScienceOn
25 Langardt S. One hundred years of chromium and cancer: A review of epidemiological evidence and selected case reports, Am. J. Ind. Med. 1990; 17: 189-215   DOI   ScienceOn
26 Hansen K and Stern RM. Welding fumes and chromium compounds in cell transformation assays, J. Appl. Toxicol. 1985; 5: 306-314   DOI   PUBMED
27 Costa M. Toxicity and carcinogenicity of Cr (VI) in animal models and humans, CRC Critical Reviews in Toxicology 1997; 27: 431-442   DOI   PUBMED   ScienceOn
28 Cupo DY and Wetterhahn KE. Modification of chromium (VI)-induced DNA damage by glutathione and cyto-chromes P-450 in chick embryo hepatocytes, Proc. Natl. Acad. Sci. USA 1985; 82: 6755-6759   DOI   ScienceOn
29 Mao Y, Zang L and Shi X. Generation of free radicals by Cr (IV) from lipid hydroperoxides and its inhibition by chelators, Biochem. Mol. Biol. Int. 1995; 36: 327-337
30 DeFlora S, Bagnsco M, Serra D and Zanacchi P. Genotoxicity of chromium compounds: A rewiew, Mutat. Res. 1990; 238: 99-172   DOI
31 Sugiyama M, Tsuzuki K and Ogura R. Effects of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromate in Chinese hamster V-79 cells treated with sodium (VI), J. Biol. Chem. 1991b; 266: 3383-3386
32 Snow E. Metal carcinogenesis: Mechanistic implications, Pharmacol. Ther. 1992; 53: 31-65   DOI   PUBMED   ScienceOn
33 Brambilla G, Martelli A and Marinari UM. Is lipid peroxidation associated with DNA damage?, Mutat. Res. 1989; 214: 123-127   DOI
34 Shi X and Dalal NS. On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium (V) species, Arch. Biochem. Biophys. 1990; 277: 342-350   DOI   ScienceOn
35 Sugiyama M. Effects of vitamins on chromium (VI)-induced damage, Environ. Health Perspect. 1991; 92: 63-70   DOI
36 Sun Y and Oberley LW. Redox regulation of transcriptional activators, Free Radical Biol. Med. 1996; 21: 335-348   DOI   ScienceOn
37 Hamilton JW and Wetterhahn KE. Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo, Carcinogenesis 1986; 7: 2085-2088   DOI   ScienceOn
38 Shi X, Leonard S, Zang L, Gannett P, Rojanasakul Y, Castranova V and Vallyathan V. Cr(III)-mediated hydroxyl radical generation via Haber-Weiss cycle, J. Inorg. Biochem. 1998; 69: 263-268   DOI   ScienceOn
39 Tsapakos MJ and Wetterhahn KE. Interaction of chromium with nucleic acids, Chern. Biol. Interact. 1983; 46: 265-277   DOI   ScienceOn
40 Ottenwalder H, Wiegand HJ and Bolt HM. Uptake of $^{51}Cr$ (VI) by human erythrocytes: Evidence for a carriermediated transport mechanism, Sci. Total Environ. 1988; 71: 561-566   DOI   ScienceOn
41 Shi X and Dalal NS. Free radical generation by mineral ions adsorbed on mineral dust: A mechanism for chronic lung injury, Respirable dust in the mineral industries, Franz RL and Ramani RV (Eds.). Littleton, Co. 1991; 307-311
42 Sugiyama M. Role of paramagnetic chromium in chromium (VI)-induced damage in cultured mammalian cells, Environ. Health perspect. 1994; 102(suppl.): 31-33
43 Suzuki Y and Fukuda K. Reduction of hexavalent chromium by ascorbic acid and glutathione with special reference to the rat lung, Arch. Toxicol. 1990; 64: 169-176   DOI   ScienceOn
44 US Public Health Service. Health of workers in chromate producing industry, US Department of Health, Education and Welfare Publ, US Government Printing Office, 1953: 192
45 Shi X and Dalal NS. The role of superoxide radical in chromium (VI) generated hydroxyl radical: The Cr (VI) Haber-Weiss cycle, Arch. Biochem. Biophys. 1992; 292: 323-327   DOI   ScienceOn
46 Buttner B and Beyersmann D. Modification of the erythrocyte anion carrier by chromate, Xenobiotica 1985; 15: 735-741   DOI   ScienceOn
47 Ji L, Arcinas M and Boxer LM. NF-$\kappa B$ sites function as positive regulators of expression of the translocated c-myc allelle in Burkitt's lymphoma, Mol. Cell Biol. 1994; 14: 141-179