Browse > Article

Antioxidant and Liver-protective Effects of Caesalpinia sappan  

Ha, Hun (Dept of Food Science and Technology, Taegu Polytechnic College)
Publication Information
Environmental Analysis Health and Toxicology / v.17, no.3, 2002 , pp. 261-264 More about this Journal
Abstract
The heartwood of Caeralpinia sappan L. (Leguminosae) has been used to activate blood flow, remove blood stasis, reduce swelling and relieve pain in Korean folk medicine. In this study. the antioxidant effects of this crude drug and its hepatoprotective activity on CCl$_4$-induced liver injury in rats were evaluated. The levels of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) reduced by CCl$_4$treatment, were recovered by this crude drug. It is suggested that Caesalpinia sappan L. have antioxidant effect. The increased levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) by CCl$_4$were also recovered by treatment with this crude drug. These results can be attributed to the agent's antioxidant and membrane - stabilizing actions.
Keywords
Caesalpinia sappan L.; $CCl_4$; GOT; GPT; Superoxide dismutase; Catalase;
Citations & Related Records
연도 인용수 순위
  • Reference
1 本草學, 大韓藥師會, 1995, 529
2 Lowry OH, Rosebrough NJ, Farr AL and Randall RJ. Protein measurement with the Folin reagent. J. Biol. chem. 1951; 193 : 265
3 Mourelle M, Muriel P, Favari L and Franco T. Prevention of $CCl_{4}$-induced liver cirrhosis by silymarin. Fundam Clin Pharmacol. 1989; 3(3) : 183-191   DOI   ScienceOn
4 Nagai M, Nagumo S, Lee SM, Eguchi I and Kawai Kl. Protosappanin A, A novel biphenyl compound from Caesalpinia sappan lignum. Chem. Pharm. Bull. 1986; 34(1-6)
5 Recknagel RO and Glende EA Jr. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit. Rev. Toxicol. 1973; 2(3) : 263-297   DOI
6 Marklund S and Marklund. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem., 1974; 47: 469   DOI   ScienceOn
7 Baek NI, Jeon SG, Ahn EM, Hahn JT, Bahn JH, Jang JS, Cho SW, Park JK, Choi and SY. Anticonvulsant compounds from the wood of Caesalpinia sappan L. Arch. Pharm. Res. 2000; 23(4) : 344-348   DOI   ScienceOn
8 Xie YW, Ming DS, Xu HX, Dong H and But PP. Vasorelaxing effects of Caesalpinia sappan involvement of endogenous nitric oxide. Life Sci. 2000; 1; 67(15) : 1913-1918   DOI   ScienceOn
9 Oh SR, Kim DS, Lee IS, Jung KY, Lee JJ and Lee HK. Anticomplementary activity of constituents from the heartwood of Caesalpinia sappan. Planta. Med. 1998; 64(5) : 456-458   DOI   ScienceOn
10 Cohen GD, Demblic and Marcus. Measurement of catalase activity in tissue extracts. Anal. Biochem. 1970; 34 : 30   DOI   ScienceOn
11 Das D, Pemberton PW, Burrows PC, Gordon C, Smith A, McMahon RF and Warnes TW. Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis. Biochim. Biophys. Acta. 2000; 15; 1502(3) : 351-362   DOI
12 Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE and Walborg EF Jr. The role of oxidative stress in chemical carcinogenesis. Environ. Health Perspect. 1998; 106(1) : 289-295   DOI
13 Nadkarni GD and D.Souza NB. Hepatic antioxidant enzymes and lipid peroxidation in carbon tetrachloride-induced liver cirrhosis in rats. Biochem. Med. Metab. Biol. 1988; 40(1) : 42-45   DOI   ScienceOn
14 Lin CC, Huang PC and Lin JM. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am. J. Chin. Med. 2000; 28(1) : 87-96   DOI   ScienceOn