Browse > Article

Effects of an Extract from A. gmelini Weber on Hepatotoxicity Induced by $CCl_4$in Rats - II. Some Dosage Effects of an Extract from A. gmelini on Hepatotoxicity Induced by $CCl_4$in Rats  

권진욱 (국립수의과학검역원)
이규승 (충남대학교 농화학과)
Publication Information
Environmental Analysis Health and Toxicology / v.17, no.2, 2002 , pp. 175-185 More about this Journal
Abstract
To investigate effects of A. gmelini on the 14-day CCl$_4$induced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 50, 500, 5,000 mg/kg b.w. to administer orally everyday and same concentration (1 : 9, CCl$_4$: olive oil v/v) of CCl$_4$administered intraperitoneally with 2.5 ml/kg b.w. On the 7th day, hemanalysis showed following recovery values; AST 9.9∼64.6%, ALT 36.9∼71.9%, ALP 75.3∼93.7％, BUN 53.8∼59.7%, TBIL 60.4∼100.0< ％, TCHO 77.7∼100.0< ％, and TG 60.4∼100.0< ％. Even if, 14-day CCl$_4$induced hepatotoxicity recovery was found to depend on doses of extract, and recovery values of each treatment were AST 13.8∼56.4％, ALT 15.7∼68.0％, ALP 53.4∼84.4％, BUN 76.9∼100.0< ％, TBIL 60.4 ∼ 100.0< %, TCHO 82.6∼99.3< ％, and TG 56.7∼99.7%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered.
Keywords
A. gmelini extract; $CCl_4$induced hepatotoxicity; lipid peroxidation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Coleman JB, Condie LW, Lamb RG. The role of $CCl_4$ biotransfomation in the activation of hepatocyte phospholipase C in vivo and in vitro, Toxicol Appl Pharmacol, 1988; 95: 208-219   DOI   ScienceOn
2 Duncan JR and Prasse KW. Verterinary Clinical MedicineClinical Pathology, 1986; 2nd ed., 1-285. Iowa State University Press, Ames, IA
3 Oelberg DG and Lester R. Cellular mechanisms of cholestasis, Annu. Rev. Med., 1986; 37: 297-317   DOI   ScienceOn
4 Recknagel RO, Glende EA. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage, CRC Crit Rev Toxicol, 1973; 2: 263-297   DOI   PUBMED
5 Cheeseman KH, Albano EF, Tomai A et al. Biochemical studies on the metabolic activation of halogenated alkanes, Environ Health Perspect, 1985; 64: 85-101   DOI   PUBMED
6 Badr MZ, Ganey PE, Yoshihara H, Kauffman FC and Thurman RG. Hepatotoxicity of menadione predominates in oxygen-rich zone of liver lobule, J. Pharmacol. Exp. Ther., 1989; 248(3): 1317-1322
7 Benedetto C and Slater TF. Tissue Sampling and Preparation, in Prostaglanins and Related Substance, IRL Press, 1987; 29, Oxford, Washington DC
8 Forni IG, Packer JE, Salter TF and Wilson RL. Reaction of the trichloromethyl and halothane-derived peroxy radicals with unsaturated fatty acids, Chem. Biol. Interact., 1983; 45: 171-177   DOI   ScienceOn
9 Philips MJ, Poucell Sand Oda M. Mechanisms of cholestasis, Lab. Invest., 1986; 54: 593-608   DOI
10 Plaa GL. Evaluation of liver function methodology. In Selected Pharmacology Testing Methods, Medical Research Series, Vol.III, edited by A. Burger, 1968; 255-288, Marcel Dekker, New York
11 Ganey PE, Kauffman FC and Thurman RG. Oxygen dependent hepatotoxicy due to doxorubicin, Mol. Pharmacol., 1988; 134: 695-701
12 Zimmerman HJ. Hepatotoxicity, Appleton-Century-Crofs, 1978; 198, New York
13 Timbrell JA. Biotransformation of Xenobiotics, In: Ballantyne, B., Marrs, T., Tuner, P. ed., General & Applied Toxicology, 1993; Vol 1. Wimbledon: M Stockton Press, 112
14 Plaa GL and Priestly BG. Intrahepatic cholestasis induced by drugs and chemicals, Pharmacol. Rev., 1976; 28 : 207-273
15 Recknagel RO. A new direction in the study of carbon tetrachloride hepatotoxicity, Life Science, 1983; 33(5): 401-408   DOI   PUBMED   ScienceOn
16 Badr MZ, Belinsky SA, Kauffman FC and Thurman RG. Mechanism of hepatotoxicity to peripotal rigions of the liver lobule due to allyl alcohol; Role of oxygen and lipid peroxidation, J. Pharmacol. Exp. Ther., 1993; 238(3): 1138-1142
17 Burk RF, Lane JM and Patel K. Relationship of oxygen and glutathion in protection against CC$l_4$ induced hepatic microsomal lipid peroxidation and covalent binding in the rat., J. Clin. Invest., 1984; 74: 1996-2001   DOI
18 Hodgson E and PE Levi A Textbook of Modem Toxicology (2nd ed), Appleton & Lange, 1997; 203-205, East Norwalk, Conneticut, USA
19 Comporti M. Biology of Disease: Lipid peroxidation and cellular damage in toxic liver injury, Lab Invest, 1985; 53(6): 599-623
20 Connor HD, Thurman RG, Galizi MD and Mason RP. The formation of novel free radical metabolite from $CCl_4$ in the perfused rat liver and in vivo JI. Biol. Chem. 1986; 26(10) : 4542-4548
21 강호석외 15인 공저. 조직학, 고문사, 1993; 서울