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Application and Optimization of the IsoButoxycarbonyl Derivatization method to the Analysis of Trace Level Phenols in Environmental Samples  

Kim, Hyub (Technology Innovation center, Sangju National University,Department of Chemistry, Woosuk University)
Hong, Jong-Ki (Hazardous Substance Research Team, Korea Basic Science Institute)
Kim, Yong-Hwa (Korea Research Institute of Chemical Technology)
Kim, Kyoung-Rae (Department of Pharmacy, SungKyunKwan University)
Publication Information
Environmental Analysis Health and Toxicology / v.17, no.1, 2002 , pp. 37-51 More about this Journal
Abstract
Eleven phenols including two chlorophenols, eight alkylphenols and bisphenol A were derivatized with isobutylchloroformate to form their isobutoxycarbonyl derivatives. Standard phenol mixture was concentrated for the isobutoxycarbonyl (isoBOC) derivatization and analysed by gas chromatography/mass spectrometry (GC/MS). The recoveries of the derivatization method of alkylphenols, chlorophenols, and bisphenol A were calculated by gas chromatography/mass spectrometry-selected ion monitoring mode using two work-up methods for comparison; shaking and heating method. The linear detector responses were obtained in the concentration range of 5∼400 ng, with correlation coefficients varying from 0.9755∼0.9981. Recoveries of the alkylphenols, chlorophenols, and bisphenol A were determined by gas chromatography/mass spectrometry-selected ion monitoring mode using two work-up methods for comparison ; the US-EPA method and the isoBOC derivatization method, Eleven phenols in water samples were extracted with dichloromethane and then concentrated. Also, solid-phase extraction (SPE) with XAD-4 and subsequent conversion to isobutoxycarbonyl derivatives for sensitive analysis with the selected ion-monitoring (SIM) mode. The recoveries were 85.1∼109.9％ and 90.3∼126.6％ for the US-EPA method and the isoBOC.
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