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Evaluation of the Potential Human Health Risk Associated with the Microcystin Bioaccumulation in the Freshwater Fish from Lake Yeongcheon and Lake Daecheong  

Lee, Kyung-Lak (Department of Forenscic Medicine, National Institute of Scientific Investigation)
Jheong, Weon-Hwa (Department of Biology, Kyungpook National University)
Kang, Young-Hoon (Department of Biology, Kyungpook National University)
Kim, Han-Soon (Department of Biology, Kyungpook National University)
Publication Information
Korean Journal of Ecology and Environment / v.42, no.3, 2009 , pp. 331-339 More about this Journal
Abstract
This study evaluated the potential human health risk on the basis of the level of bioaccumulation and EDI (Estimated Daily Intake) of microcystin-LR, one of hepatotoxic, in organs, including liver, muscle, viscera and gill, of fish from Lake Yeongeheon and Lake Daecheong when the cyanobacterial water-blooms broke out. The result has confirmed that Carassius cuvieri from Lake Yeongcheon contains higher level of microcystin-LR in its organs including liver. In Lake Daecheong, omnivorous Hemibarbus labeo and phytoplanktivorous Carassius cuvieri have shown high microcystin-LR level on average, especially higher for viscera, and Carassius cuvieri has appeared to contain higher level of microcystin-LR in the liver and the gill compared with other species. As a result of comparison between EDI of microcystin-LR from each organs and TDI (Tolerable Daily Intake) of WHO (Chorus and Bartram, 1999) to evaluate human health risk, the EDI levels from Carassius cuvieri's organs except museles have exceeded TDI level at the both lakes. Consequently, the study has proved that microcystin was bioaccumulated in the various parts of fish, and it can be ingested by human resulting in risking human health. Continuous monitoring and reducing consumption of fish, especially Carassius cuvieri, during the cyanobacterial water-blooming period will be needed to protect human health.
Keywords
human health risk; microcystin-LR; Fish; TDI; Carassius cuvieri;
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1 이경락, 정원화, 김종민, 김영생, 최희진, 김한순. 2008. 영천호에서 남조류독소(microcystins)의 계절적 변동. 한국하천호수학회지 41: 264-274   과학기술학회마을
2 Chorus, I. and J. Bartram. 1999. Toxic Cyanobacteria in Water: A Guide to Their Public Health Consequences, Monitoring, and Management. SPON Press, on behalf of the World Health Organization
3 Fawell, J.K, C.P. James and H.A James. 1994. Toxins from blue-green algae: Toxicological assessment of microcystin-LR and a method for its determination in water. Water Research Centre, Medmenham
4 Honkanen, RE., J. Zwiller, RE. Moore, S.L. Daily, B.S. Khatra, M. Dukelow and AL. Boynton 1990. Characterization ofmicrocystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J. Biol. Chem. 265: 19401-19404   PUBMED
5 Ibelings, B.W. and I. Chorus. 2007. Accumulation of cyanobacterial toxins in freshwater "seafood" and its consequences for public health: A review. Environ. Pollut. 150: 177-192   PUBMED
6 Magalhiies, V.F., M.M. Marino, P. Domingos, AC. Oliveira, S.M. Costa, L.O. Azevedo and S.M.F.O. Azevedo. 2003. Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ). Toxieon 42: 289-295
7 Oh, H.-M., S.J. Lee, J.-H. Kim, H.-S. Kim and B.-D. Yoon. 2001. Seasonal variation and indirect monitoring of microcystin concentration in Daechung Reservoir, Korea. Appl. Environ. Mierobiol. 67: 1484-1489
8 Sivonen, K. and J. Jones. 1999. Cyanobacterial toxins. p. 41-112. In: Toxic cyanobacteria in water. A guide to their public health consequences, monitoring and management (Chorus I. and J. Bartram, eds.). World Health Organization, Geneva
9 Fastner, J., U. Neumann, B. Wirsing, J. Weckesser, C. Wiedner, B. Nixdorf and I. Chorus. 1999. Microcystins (Hepatotoxic heptapeptides) in German fresh water bodies. Environ. Toxieol. 14: 13-22   DOI
10 Ressom, R., F.S. Soong, J. Fitzgerald, L. Turczynowicz, O. El Saadi, D. Roder, T. Maynard and I. Falconer. 1994. Health effects of toxic cyanobacteria (blue-green algae), National Health and Medical Research Council, Australia
11 Zhang, D., P. Xie, Y. Liu and T. Qiu. 2008. Transfer, distribution and bioaccumulation of microcystins in the aquatic food web in Lake Taihu, China, with potential risks to human health. Sci. Total Environ. 407: 2191-2199
12 최기철, 전상린, 김익수, 손영목. 1990. 원색한국담수어도감. 향문사
13 Gkelis, S., T. Lanaras and S. Sivonen. 2006. The presence of microcystins and other cyanobacterial bioactive peptides in aquatic fauna collected from Greek freshwaters. Aqua. Toxieol. 10: 32-41   DOI   ScienceOn
14 Wilson, A.E., D.C. Gossiaux, T.O. HooK, J.P. Berry, P.F. Landrum, J. Dyble and S.J. Guildford. 2008. Evaluation of the human health threat associated with the hepatotoxin microcystin in the muscle and liver tissues of yellow perch (Perea flaveseens). Can. J. Fish Aquat. Sci. 65: 1487-1497   DOI   ScienceOn
15 Fischer, W.J. and D.R Dietrich. 2000. Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxieol. Appl. Pharmaeol. 164: 73-81   DOI   ScienceOn
16 Dietrich, D. and S. Hoeger. 2005. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach? Toxicol. Appl. Pharmacol. 203: 273-289   DOI   ScienceOn
17 Harada, K-I., K Tsuji, M.F. Watanabe and F. Kondo. 1996. Stability of microcystins from cyanobacteria. III. Effect of pH and temperature. Phyeologia 35: 83-88
18 MacKintosh, C., KA Beattie, S. Klumpp, P. Cohen and G.A. Codd. 1990. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264: 187-192   DOI   ScienceOn
19 Magalhiies, V.F., RM. Soares and S.M.F.O. Azevedo. 2001. Microcystin contamination in fish from the Jacarepagua Lagoon (Rio de Janeiro, Brazil): ecological implication and human health risk. Toxieon 39: 1077-1108
20 Craig M., H.A. Luu, T.L. Mccready, D. Williams, RJ. Andersen and C.F.B. Holmes. 1996. Molecular mechanisms underlying the interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases. Bioehem. Cell Biol. 74: 569-578   DOI   ScienceOn
21 Xie, L.Q., P. Xie, L.G. Guo, L. Li, Y. Miyavara and H.-D. Park. 2005. Organ distribution and bioaccumulation of microcystins in freshwater fish at different trophic levels from the eutrophic Lake Chaohu, China. Environ. Toxieol. 20: 293-300   DOI   ScienceOn
22 Falconer, I. 1999. An review of problems caused by toxic blue-green algae (cyanobacteria) in drinking water. Environ. Toxieol. 14: 5-12   DOI
23 Watzin, M.C., E.B. Miller, A.D. Shambaugh and M.A. Kreider. 2006. Application of the WHO alert level framework to cyanobacterial monitoring of Lake Champlain, Vermont. Environ. Toxieol. 21: 278-288   DOI   ScienceOn
24 국립환경과학원. 2005. 2005년도 조류예보제 시행결과보고서. 국립환경과학원, 인천
25 WHO. 1998. Guidelines for drinking water quality, 2nd edition. Addendum to volume 2. Health criteria and other supporting information, World Health Organization, Geneva
26 Mohamed, Z.A, W.W. Carmichael and AA Hussein. 2003. Estimation of microcystins in the freshwater fish Oreoehromis nilotieus in an Egyptian fish farm containing a Mieroeystis bloom. Environ. Toxieol. 18: 137-141   DOI   ScienceOn
27 Preussel, K., A. Stuken, C. Wiedner, I. Chorus and J. Fastnero 2006. First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes. Toxieon 47: 156-162