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Detection of Endocrine-Disrupting Chemicals in Fish and the Use of Fish Vitellogenin as a Biomarker  

Yoon, Seok-Joo (The Research Institute for Natural Sciences, Hanyang University)
Kim, Il-Chan (Department of Biochemistry, College of Medicine, Hanyang University)
Yoon, Yong-Dal (Department of Life Science, College of Natural Sciences, Hanyang University)
Lee, Jae-Seong (Department of Environmental Science, Graduate School, Hanyang University)
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Abstract
Fish vitellogenin produces in female liver during oogensesis through estradiol cycle, and produces even in male liver by endocrine-disrupting chemicals (EDCs) such as alkylphenols. The resulting effects of EDCs lead to the low fecundity of female and the feminization (eg. shrinkage of testis) in male. Especially, the production of vitellogenin in male indicates the environmental contamination of EDCs, resulting in the modulation of gene expression profiles and the monitoring of environmental contamination at specific area. In this paper, we suggest that fish vitellogenin is useful for biomonitoring for environmental contamination and would be substantially useful as a biomarker for a detection of EDCs in aquatic environment.
Keywords
Endocrine disruptor; EDC; Fish; Vitellogenin; Biomarker;
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